[HTML][HTML] APOBECs and virus restriction
RS Harris, JP Dudley - Virology, 2015 - Elsevier
The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
Animal models for HIV/AIDS research
T Hatziioannou, DT Evans - Nature Reviews Microbiology, 2012 - nature.com
The AIDS pandemic continues to present us with unique scientific and public health
challenges. Although the development of effective antiretroviral therapy has been a major …
challenges. Although the development of effective antiretroviral therapy has been a major …
The AID/APOBEC family of nucleic acid mutators
SG Conticello - Genome biology, 2008 - Springer
The AID/APOBECs, a group of cytidine deaminases, represent a somewhat unusual protein
family that can insert mutations in DNA and RNA as a result of their ability to deaminate …
family that can insert mutations in DNA and RNA as a result of their ability to deaminate …
Retroviral restriction by APOBEC proteins
RS Harris, MT Liddament - Nature Reviews Immunology, 2004 - nature.com
A powerful mechanism of vertebrate innate immunity has been discovered in the past year,
in which APOBEC proteins inhibit retroviruses by deaminating cytosine residues in nascent …
in which APOBEC proteins inhibit retroviruses by deaminating cytosine residues in nascent …
APOBEC enzymes as targets for virus and cancer therapy
Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …
The APOBEC3 family of retroelement restriction factors
EW Refsland, RS Harris - Intrinsic immunity, 2013 - Springer
The ability to regulate and even target mutagenesis is an extremely valuable cellular asset.
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …
Enzyme-catalyzed DNA cytosine deamination is a molecular strategy employed by …
The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements
YL Chiu, WC Greene - Annu. Rev. Immunol., 2008 - annualreviews.org
All retroviruses, including HIV-1, display species-specific patterns of infection. The impaired
growth of these retroviruses in foreign and sometimes even in their natural hosts often stems …
growth of these retroviruses in foreign and sometimes even in their natural hosts often stems …
APOBEC3 proteins in viral immunity
S Stavrou, SR Ross - The Journal of Immunology, 2015 - journals.aai.org
Apolipoprotein B editing complex 3 family members are cytidine deaminases that play
important roles in intrinsic responses to infection by retroviruses and have been implicated …
important roles in intrinsic responses to infection by retroviruses and have been implicated …
Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all
BA Desimmie, KA Delviks-Frankenberrry… - Journal of molecular …, 2014 - Elsevier
Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
HIV-1 Vif, APOBEC, and intrinsic immunity
R Goila-Gaur, K Strebel - Retrovirology, 2008 - Springer
Members of the APOBEC family of cellular cytidine deaminases represent a recently
identified group of proteins that provide immunity to infection by retroviruses and protect the …
identified group of proteins that provide immunity to infection by retroviruses and protect the …