[HTML][HTML] Characterization of the HER2 status in BRCA-mutated breast cancer: a single institutional series and systematic review with pooled analysis
G Tomasello, D Gambini, F Petrelli, J Azzollini… - Esmo Open, 2022 - Elsevier
Background Pathogenic variants (PVs) in BRCA1/2 genes account for∼ 6% of breast and
20% of ovarian cancers. Most breast tumors developed by BRCA1 carriers are triple …
20% of ovarian cancers. Most breast tumors developed by BRCA1 carriers are triple …
[HTML][HTML] The management of BRCA1 and BRCA2 carriers in Singapore
Singapore is a densely populated small island nation, with a multiethnic and multireligious
population. Cancer is the leading cause of death in Singapore. The population is well …
population. Cancer is the leading cause of death in Singapore. The population is well …
Evaluating BRCA mutation risk predictive models in a Chinese cohort in Taiwan
Accurate estimation of carrier probabilities of cancer susceptibility gene mutations is an
important part of pre-test genetic counselling. Many predictive models are available but their …
important part of pre-test genetic counselling. Many predictive models are available but their …
Increased incidence of pathogenic variants in ATM in the context of testing for breast and ovarian cancer predisposition
P Macquere, S Orazio, F Bonnet, N Jones… - Journal of Human …, 2022 - nature.com
Pathogenic Variants (PV) in major cancer predisposition genes are only identified in
approximately 10% of patients with Hereditary Breast and Ovarian Cancer (HBOC) …
approximately 10% of patients with Hereditary Breast and Ovarian Cancer (HBOC) …
High frequency of pathogenic non-founder germline mutations in BRCA1 and BRCA2 in families with breast and ovarian cancer in a founder population
J Maksimenko, A Irmejs, G Trofimovičs… - Hereditary cancer in …, 2018 - Springer
Background Pathogenic BRCA1 founder mutations (c. 4035delA, c. 5266dupC) contribute to
3.77% of all consecutive primary breast cancers and 9.9% of all consecutive primary ovarian …
3.77% of all consecutive primary breast cancers and 9.9% of all consecutive primary ovarian …
Assessment and profiling of FLASH-induced cellular DNA damage as mechanistic markers of the 'FLASH effect'.
CR Cooper - 2024 - figshare.le.ac.uk
Several studies have reported the normal tissue-sparing effects of ultra-high dose rate
'FLASH'irradiation in vivo whilst maintaining tumour response, with an associated reduced …
'FLASH'irradiation in vivo whilst maintaining tumour response, with an associated reduced …
The Manchester Scoring System for predicting BRCA1/2 mutations underperforms in Arabic Omani breast cancer patients
C van Wyk, H Al‐Sayegh, SI Al‐Kiyumi… - Journal of Genetic … - Wiley Online Library
Risk assessment models that are applied to assess the lifetime risk of cancer and
pathogenic variant risk are more commonly used in Western populations. Using these …
pathogenic variant risk are more commonly used in Western populations. Using these …