Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet - Pharmacological reviews, 2018 - ASPET
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Towards a unified mechanistic theory of aging

G Barja - Experimental gerontology, 2019 - Elsevier
A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …

[HTML][HTML] Lipidomics reveals a tissue-specific fingerprint

I Pradas, K Huynh, R Cabré, V Ayala, PJ Meikle… - Frontiers in …, 2018 - frontiersin.org
In biological systems lipids generate membranes and have a key role in cell signaling and
energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the …

The highly unnatural fatty acid profile of cells in culture

PL Else - Progress in lipid research, 2020 - Elsevier
The fatty acid profile of cells in culture are unlike those of natural cells with twice the
monounsaturated (MUFA) and half the polyunsaturated fatty acids (PUFA) level (Mol%). This …

Phenotypic molecular features of long-lived animal species

M Jové, N Mota-Martorell, A Fernàndez-Bernal… - Free Radical Biology …, 2023 - Elsevier
One of the challenges facing science/biology today is uncovering the molecular bases that
support and determine animal and human longevity. Nature, in offering a diversity of animal …

Looking beyond structure: membrane phospholipids of skeletal muscle mitochondria

TD Heden, PD Neufer, K Funai - Trends in Endocrinology & Metabolism, 2016 - cell.com
Skeletal muscle mitochondria are highly dynamic and are capable of tremendous expansion
to meet cellular energetic demands. Such proliferation in mitochondrial mass requires a …

[HTML][HTML] The lipidome fingerprint of longevity

M Jové, N Mota-Martorell, I Pradas, JD Galo-Licona… - Molecules, 2020 - mdpi.com
Lipids were determinants in the appearance and evolution of life. Recent studies disclose
the existence of a link between lipids and animal longevity. Findings from both comparative …

[HTML][HTML] Dietary squalene supplementation decreases triglyceride species and modifies phospholipid lipidomic profile in the liver of a porcine model of non-alcoholic …

LV Herrera-Marcos, R Martínez-Beamonte… - The Journal of …, 2023 - Elsevier
Squalene is a key minor component of virgin olive oil, the main source of fat in the
Mediterranean diet, and had shown to improve the liver metabolism in rabbits and mice. The …

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles

JM Hinkley, HH Cornnell, RA Standley, EY Chen… - Aging …, 2020 - Wiley Online Library
The loss of skeletal muscle mass and function with age (sarcopenia) is a critical healthcare
challenge for older adults. 31‐phosphorus magnetic resonance spectroscopy (31P‐MRS) is …

Honey bee caste lipidomics in relation to life-history stage and the long life of the queen

N Martin, AJ Hulbert, GC Brenner… - Journal of …, 2019 - journals.biologists.com
Honey bees have evolved a system in which fertilised eggs transit through the same
developmental stages but can become either workers or queens. This difference is …