The development of thrombotic disorders in humans is one of the most common causes of
morbidity and mortality in the Western world. Thrombotic disease can be classified in broad …

Activated factor VII (FVIIa), the first protease of clotting, expresses its physiological
procoagulant potential only after complexing with tissue factor (TF) exposed to blood. Deep …

ContextTumor necrosis factor alpha (TNF-α) is believed to be a cytokine central to
pathogenesis of septic shock. TNF2, a polymorphism within the TNF-α gene promoter, has …

Background: The prevalence of duodenal carcinoma is much higher in familial
adenomatous polyposis (FAP) than in the background population, and duodenal …

Background Although epidemiologic studies have suggested that several genetic variants
increase the risk of myocardial infarction, large-scale association studies that examine many …

Although there are a number of well-characterized genetic defects that lead to increased risk
of thrombosis, little information is available on the relative importance of genetic factors in …

Plasma fibrinogen is a major determinant of platelet aggregation and blood viscosity. The
decrease in plasma fibrinogen by bezafibrate is associated with a decrease in the risk of …

We describe here a system for the rapid identification, assay development, and
characterization of gene-based single nucleotide polymorphisms (SNPs). This system …

Background—Thrombosis is a pivotal event in the pathogenesis of coronary disease. We
hypothesized that the presence of blood factors that reflect enhanced thrombogenic activity …

Background High plasma levels of coagulation factor VII have been suggested to be
predictors of death due to coronary artery disease. Since polymorphisms in the factor VII …