Inositol 1, 4, 5-trisphosphate receptors (IP3Rs), by releasing Ca2+ from the endoplasmic
reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or …

Abstract The inositol 1, 4, 5-trisphosphate (IP 3) receptor (IP 3 R) is a Ca 2+-release channel
mainly located in the endoplasmic reticulum (ER). Three IP 3 R isoforms are responsible for …

Background The development of the rumen is an important physiological challenge for
young ruminants. Previous studies have shown that starter feeding can effectively facilitate …

Neurological diseases are relatively complex diseases of a large system; however, the
detailed mechanism of their pathogenesis has not been completely elucidated, and effective …

Calcium signaling in health, disease and therapy Calcium signaling in health, disease and
therapy Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1657-1659. doi …

Proteinuria is a common clinical manifestation of kidney diseases, such as
glomerulonephritis, nephrotic syndrome, immunoglobulin A nephropathy and diabetic …

Several integral membrane proteins undergo regulated intramembrane proteolysis (RIP), a
tightly controlled process through which cells transmit information across and between …

The incidence of breast cancer (BC) has been increasing each year, and BC is now the most
common malignant tumor in women. Among the numerous BC subtypes, HER2-positive BC …

We previously identified a nuclear variant of bone morphogenetic protein 2 (BMP2), named
nBMP2, that is translated from an alternative start codon. Decreased nuclear localization of …

Intracellular calcium (Ca 2+) signaling regulates a variety of physiological functions in
epithelial cells. Specifically, Ca 2+ is critical in controlling fluid and electrolyte secretion …