Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The
clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor …

Motor neuron disease is an umbrella term encompassing a multitude of clinically
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …

Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …

Magnetic resonance spectroscopy (MRS) has contributed important academic insights in
motor neuron diseases (MNDs), particularly in amyotrophic lateral sclerosis (ALS). Over the …

Motor neuron diseases encompass a divergent group of conditions with considerable
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …

Pseudobulbar affect (PBA), referring to exaggerated or inappropriate episodes of laughing
and/or crying without an apparent motivating stimulus, has been mainly attributed to bilateral …

The contribution of cerebellar pathology to cognitive and behavioural manifestations is
increasingly recognised, but the cerebellar profiles of FTD phenotypes are relatively poorly …

Background: With the advances in neuroimaging in amyotrophic lateral sclerosis (ALS), it
has been speculated that multiparametric magnetic resonance imaging (MRI) is capable to …

Introduction Pseudobulbar affect (PBA) is a distressing symptom of a multitude of
neurological conditions affecting patients with a rage of neuroinflammatory, neurovascular …