Protein aggregation: pathways, induction factors and analysis
HC Mahler, W Friess, U Grauschopf, S Kiese - Journal of pharmaceutical …, 2009 - Elsevier
Control and analysis of protein aggregation is an increasing challenge to pharmaceutical
research and development. Due to the nature of protein interactions, protein aggregation …
research and development. Due to the nature of protein interactions, protein aggregation …
Analytical ultracentrifugation: sedimentation velocity and sedimentation equilibrium
Analytical ultracentrifugation (AUC) is a versatile and powerful method for the quantitative
analysis of macromolecules in solution. AUC has broad applications for the study of …
analysis of macromolecules in solution. AUC has broad applications for the study of …
Calculations and publication-quality illustrations for analytical ultracentrifugation data
CA Brautigam - Methods in enzymology, 2015 - Elsevier
The analysis of analytical ultracentrifugation (AUC) data has been greatly facilitated by the
advances accumulated in recent years. These improvements include refinements in AUC …
advances accumulated in recent years. These improvements include refinements in AUC …
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
DC Goldstone, V Ennis-Adeniran, JJ Hedden… - Nature, 2011 - nature.com
SAMHD1, an analogue of the murine interferon (IFN)-γ-induced gene Mg11 (ref.), has
recently been identified as a human immunodeficiency virus-1 (HIV-1) restriction factor that …
recently been identified as a human immunodeficiency virus-1 (HIV-1) restriction factor that …
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase
CW Garvie, X Wu, M Papanastasiou, S Lee… - Nature …, 2021 - nature.com
DNMDP and related compounds, or velcrins, induce complex formation between the
phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in …
phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in …
Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies
KE Wright, KA Hjerrild, J Bartlett, AD Douglas, J Jin… - Nature, 2014 - nature.com
Invasion of host erythrocytes is essential to the life cycle of Plasmodium parasites and
development of the pathology of malaria. The stages of erythrocyte invasion, including initial …
development of the pathology of malaria. The stages of erythrocyte invasion, including initial …
The program for processing newly synthesized histones H3. 1 and H4
EI Campos, J Fillingham, G Li, H Zheng… - Nature structural & …, 2010 - nature.com
The mechanism by which newly synthesized histones are imported into the nucleus and
deposited onto replicating chromatin alongside segregating nucleosomal counterparts is …
deposited onto replicating chromatin alongside segregating nucleosomal counterparts is …
Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein …
JCD Houtman, PH Brown, B Bowden… - Protein …, 2007 - Wiley Online Library
Multisite interactions and the formation of ternary or higher‐order protein complexes are
ubiquitous features of protein interactions. Cooperativity between different ligands is a …
ubiquitous features of protein interactions. Cooperativity between different ligands is a …
Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation
Modern computational strategies have allowed for the direct modeling of the sedimentation
process of heterogeneous mixtures, resulting in sedimentation velocity (SV) size‐distribution …
process of heterogeneous mixtures, resulting in sedimentation velocity (SV) size‐distribution …
Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila
E Brombacher, S Urwyler, C Ragaz, SS Weber… - Journal of biological …, 2009 - ASBMB
The causative agent of Legionnaires disease, Legionella pneumophila, forms a replicative
vacuole in phagocytes by means of the intracellular multiplication/defective organelle …
vacuole in phagocytes by means of the intracellular multiplication/defective organelle …