Metabolic reprogramming is a hallmark of cancer metastasis in which cancer cells
manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor …

The extracellular matrix (ECM) mechanical properties regulate key cellular processes in
tissue development and regeneration. The majority of scientific investigation has focused on …

Background Cancer invasion is a multi-step process which coordinates interactions between
tumor cells with mechanotransduction towards the surrounding matrix, resulting in distinct …

Most cancer-related deaths come from metastasis. It was recently discovered that
nanoparticles could inhibit cancer cell migration. Whereas most researchers focus on single …

Accumulating evidence suggests that the mechanical and biochemical signals originating
from cell–cell adhesion are critical for stem cell lineage specification. In this review, we focus …

Background Increasing evidence indicates that obesity is associated with tumor
development and progression. Leptin is an adipocyte-related hormone with a key role in …

Mechanical force modulates development, influences tissue homeostasis, and contributes to
disease. Forces sculpt tissue-level behaviors and direct cell fate by engaging …

Tumor cell migration, the basis for metastatic dissemination, is an adaptive process which
depends upon coordinated cell interaction with the environment, influencing cell–matrix and …

During tumor progression, cancer-associated fibroblasts (CAFs) accumulate in tumors and
produce an excessive extracellular matrix (ECM), forming a capsule that enwraps cancer …

Rationale: Bone marrow-derived mesenchymal stem cells (BM-MSCs) recruited into breast
tumors regulate the behavior of tumor cells via various mechanisms and affect clinical …