Saponins are widely distributed plant natural products with vast structural and functional
diversity. They are typically composed of a hydrophobic aglycone, which is extensively …

Tomatoes produce the bioactive compounds lycopene and α-tomatine that are reported to
have potential health-promoting effects in animals and humans, but our understanding of the …

Inhibition of cancer can occur via apoptosis, a genetically directed process of cell self-
destruction that involves numerous biomarkers and signaling pathways. Glycoalkaloids are …

Considered as the second deadliest disease globally, cancer has captured the attention of
researchers who have been trying with perseverance to decode its hidden aspects, to find …

Ethnopharmacological relevance Annona muricata known as “the cancer killer” has been
widely used in the traditional medicine for the treatment of cancer and tumors. The purpose …

Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of
increased basal oxidative stress. Since this state of oxidative stress makes cancer cells …

Saponins are bioactive compounds produced mainly by plants but also by some marine
organisms and insects. In the recent past, there has been unforeseen interest in the clinical …

Discovery and development of new potentially selective anticancer agents are necessary to
prevent a global cancer health crisis. Currently, alternative medicinal agents derived from …

Breast cancer is one of the major causes of mortality in women worldwide. The current
treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET) …

The steroidal glycoalkaloid α-tomatine (αTM) and its aglycone tomatidine (TD) are abundant
in the skin of unripe green tomato and present in tomato leaves and flowers. They mainly …