Cancer stem cells (CSCs) are a population of self-renewal cells with high tumorigenic
potency. CSCs can adopt easily with changes in the nearby milieu, and are more resistant to …

Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …

The frontotemporal dementia (FTD) spectrum of neurodegenerative disorders includes a
heterogeneous group of conditions. However, following on from a series of important …

Tumor-initiating stem cells (TSCs) are critical for drug resistance and immune escape.
However, the mutual regulations between TSC and tumor microenvironment (TME) remain …

Background Heterozygous loss-of-function mutations in the progranulin (PGRN) gene
(GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia …

Cancer research has been largely focused on the cellular and molecular levels of
investigation. Recent data show that not only the cell but also the extracellular matrix plays a …

The evolving concept that cancer stem cells (CSCs) are the driving element in cancer
development, evolution and heterogeneity, has overridden the previous model of a tumor …

Neurodegenerative diseases such as Alzheimer's disease have proven resistant to new
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …

Breast cancer is one of the most malignant diseases world-wide and ranks the first among
female cancers. Progranulin (PGRN) plays a carcinogenic role in breast cancer, but its …

Simple Summary Glioblastoma (GBM) is the most lethal adult primary brain tumor, and has
no cure. This study investigated the membrane protein sortilin as a prognosis biomarker for …