C-type lectins in immunity and homeostasis
GD Brown, JA Willment, L Whitehead - Nature Reviews Immunology, 2018 - nature.com
The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …
and that regulate a diverse range of physiological functions. Most research attention has …
CD22: a regulator of innate and adaptive B cell responses and autoimmunity
EA Clark, NV Giltiay - Frontiers in immunology, 2018 - frontiersin.org
CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized
over 30 years ago and named “CD22” in 1984 at the 2nd International workshop in Boston …
over 30 years ago and named “CD22” in 1984 at the 2nd International workshop in Boston …
Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus
SA Jenks, KS Cashman, E Zumaquero, UM Marigorta… - Immunity, 2018 - cell.com
Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity
P Holla, B Dizon, AA Ambegaonkar, N Rogel… - Science …, 2021 - science.org
Chronic infectious diseases have a substantial impact on the human B cell compartment
including a notable expansion of B cells here termed atypical B cells (ABCs). Using …
including a notable expansion of B cells here termed atypical B cells (ABCs). Using …
Implication of TIGIT+ human memory B cells in immune regulation
Regulatory B cells (Bregs) contribute to immune regulation. However, the mechanisms of
action of Bregs remain elusive. Here, we report that T cell immunoreceptor with Ig and ITIM …
action of Bregs remain elusive. Here, we report that T cell immunoreceptor with Ig and ITIM …
Toll-like receptors 7 and 9 regulate the proliferation and differentiation of B cells in systemic lupus erythematosus
L Wen, B Zhang, X Wu, R Liu, H Fan, L Han… - Frontiers in …, 2023 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune illness marked by the loss of
immune tolerance and the production of autoantibodies against nucleic acids and other …
immune tolerance and the production of autoantibodies against nucleic acids and other …
The role of semaphorins in immune responses and autoimmune rheumatic diseases
M Nishide, A Kumanogoh - Nature Reviews Rheumatology, 2018 - nature.com
Semaphorins have a well-characterized role in guiding axon repulsion during development;
however, the important contribution of these proteins in immunity is becoming increasingly …
however, the important contribution of these proteins in immunity is becoming increasingly …
T cell–dependent affinity maturation and innate immune pathways differentially drive autoreactive B cell responses in rheumatoid arthritis
DR Lu, AN McDavid, S Kongpachith… - Arthritis & …, 2018 - Wiley Online Library
Objective Rheumatoid arthritis (RA) is characterized by the activation of B cells that produce
anti–citrullinated protein antibodies (ACPA s) and rheumatoid factors (RF s), but the …
anti–citrullinated protein antibodies (ACPA s) and rheumatoid factors (RF s), but the …
Aberrant B cell signaling in autoimmune diseases
OBJ Corneth, SFH Neys, RW Hendriks - Cells, 2022 - mdpi.com
Aberrant B cell signaling plays a critical in role in various systemic and organ-specific
autoimmune diseases. This is supported by genetic evidence by many functional studies in …
autoimmune diseases. This is supported by genetic evidence by many functional studies in …
Intestinal permeability, gut inflammation, and gut immune system response are linked to aging-related changes in gut microbiota composition: a study in female mice
PE Gámez-Macías, E Félix-Soriano… - The Journals of …, 2024 - academic.oup.com
Aging entails changes at the cellular level that increase the risk of various pathologies. An
association between gut microbiota and age-related diseases has also been attributed. This …
association between gut microbiota and age-related diseases has also been attributed. This …