The domestic dog represents one of the most dramatic long-term evolutionary experiments
undertaken by humans. From a large wolf-like progenitor, unparalleled diversity in …

Osteoarthritis (OA) is a global disease that, despite extensive research, has limited treatment
options. Pet dogs share both an environment and lifestyle attributes with their owners, and a …

Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …

Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and
breed-associated behaviors resulting from human selective pressures. To identify the …

Stature is affected by many polymorphisms of small effect in humans. In contrast, variation in
dogs, even within breeds, has been suggested to be largely due to variants in a small …

There are nearly 400 modern domestic dog breeds with a unique histories and genetic
profiles. To track the genetic signatures of breed development, we have assembled the most …

Motivation Genome-wide datasets produced for association studies have dramatically
increased in size over the past few years, with modern datasets commonly including millions …

R package pcadapt is a user-friendly R package for performing genome scans for local
adaptation. Here, we present version 4 of pcadapt which substantially improves …

Domestic sheep and their wild relatives harbor substantial genetic variants that can form the
backbone of molecular breeding, but their genome landscapes remain understudied. Here …

DNA methylation profiles have been used to develop biomarkers of aging known as
epigenetic clocks, which predict chronological age with remarkable accuracy and show …