Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

The vascular endothelium is an interface between the blood stream and the vessel wall.
Changes in this single cell layer of the artery wall are believed of primary importance in the …

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Nitric oxide is an inorganic free radical gas, of formula* N= O (abbreviated as NO). The
discovery in 1987/88 that vascular endothelial cells are able to synthesize NO from L …

Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

Three isozymes of nitric oxide (NO) synthase (EC 1.14. 13.39) have been identified and the
cDNAs for these enzymes isolated. In humans, isozymes I (in neuronal and epithelial cells) …

Mechanical forces are important modulators of cellular function in many tissues and are
particularly important in the cardiovascular system. The endothelium, by virtue of its unique …

Purpose: To review the physiologic role of nitric oxide, an unusual messenger molecule that
mediates blood vessel relaxation, neurotransmission, and pathogen suppression. Data …

Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme
heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of …

Redox signalling in the gastrointestinal mucosa is held in an intricate balance. Potent
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …