Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs

C Tuftee, E Alsberg, IT Ozbolat, M Rizwan - Trends in Biotechnology, 2024 - cell.com
Advancements in 3D bioprinting have been hindered by the trade-off between printability
and biological functionality. Existing bioinks struggle to meet both requirements …

Emerging perspectives on 3D printed bioreactors for clinical translation of engineered and bioprinted tissue constructs

M Thangadurai, SS Srinivasan, MP Sekar… - Journal of Materials …, 2024 - pubs.rsc.org
3D printed/bioprinted tissue constructs are utilized for the regeneration of damaged tissues
and as in vitro models. Most of the fabricated 3D constructs fail to undergo functional …

Fine‐tuning Dynamic Cross–linking for Enhanced 3D Bioprinting of Hyaluronic Acid Hydrogels

S Tavakoli, N Krishnan, H Mokhtari… - Advanced Functional …, 2024 - Wiley Online Library
Abstract 3D bioprinting of stem cells shows promise for medical applications, but the
development of an efficient bioink remains a challenge. Recently, the emergence of …

Design parameters for injectable biopolymeric hydrogels with dynamic covalent chemistry crosslinks

N de Paiva Narciso, RS Navarro… - Advanced …, 2023 - Wiley Online Library
Dynamic covalent chemistry (DCC) crosslinks can form hydrogels with tunable mechanical
properties permissive to injectability and self‐healing. However, not all hydrogels with …

Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds

Y Liu, AE Gilchrist, SC Heilshorn - Advanced Materials, 2024 - Wiley Online Library
The biochemical and biophysical properties of the extracellular matrix (ECM) play a pivotal
role in regulating cellular behaviors such as proliferation, migration, and differentiation …

Structure–Reactivity Relationships in a Small Library of Imine-Type Dynamic Covalent Materials: Determination of Rate and Equilibrium Constants Enables Model …

FLC Morgan, IAO Beeren, J Bauer… - Journal of the …, 2024 - ACS Publications
The development of next generation soft and recyclable materials prominently features
dynamic (reversible) chemistries such as host–guest, supramolecular, and dynamic …

Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry

BG Soliman, AK Nguyen, JJ Gooding… - Advanced …, 2024 - Wiley Online Library
Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical
and mechanical nature of native tissues are needed for advanced models of development …

Near-Infrared Light-Activatable DNA Tentacles for Efficient Inhibition of Tumor Metastasis by Bio-Orthogonal Cell Assembly

L Cao, X Yang, Y Li, Y Yang, Q Liu, M Bottini, Y Jin… - ACS …, 2024 - ACS Publications
Tumor metastasis remains a major challenge in cancer management. Among various
treatment strategies, immune cell-based cancer therapy holds a great potential for inhibiting …

Transient Competitors to Modulate Dynamic Covalent Cross-Linking of Recombinant Hydrogels

AE Gilchrist, Y Liu, K Klett, YC Liu, S Ceva… - Chemistry of …, 2023 - ACS Publications
Hydrogels cross-linked by dynamic covalent chemistry (DCC) are stiff and remodelable,
making them ideal biomimetics for tissue engineering applications. Due to the reversibility of …

Shear Thickening Behavior in Injectable Tetra-PEG Hydrogels Cross-Linked via Dynamic Thia-Michael Addition Bonds

AD Crowell, TM FitzSimons, EV Anslyn… - …, 2023 - ACS Publications
Injectable poly (ethylene glycol)(PEG)-based hydrogels were reversibly cross-linked through
thia-conjugate addition bonds and demonstrated to shear thicken at low shear rates. Cross …