The acute respiratory distress syndrome

MA Matthay, LB Ware… - The Journal of clinical …, 2012 - Am Soc Clin Investig
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory
failure that is often associated with multiple organ failure. Several clinical disorders can …

Mesenchymal stem cells in tissue repair

AM DiMarino, AI Caplan, TL Bonfield - Frontiers in immunology, 2013 - frontiersin.org
The advent of mesenchymal stem cell (MSC)-based therapies for clinical therapeutics has
been an exciting and new innovation for the treatment of a variety of diseases associated …

Intravenous infusion of human umbilical cord Wharton's jelly-derived mesenchymal stem cells as a potential treatment for patients with COVID-19 pneumonia

Y Zhang, J Ding, S Ren, W Wang, Y Yang, S Li… - Stem cell research & …, 2020 - Springer
The novel coronavirus disease 2019 (COVID-19) has grown to be a global public health
emergency since patients were first detected in Wuhan, China. Thus far, no specific drugs or …

Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices

RR Sharma, K Pollock, A Hubel, D McKenna - Transfusion, 2014 - Wiley Online Library
Mesenchymal stem cells (MSC s) have recently generated great interest in the fields of
regenerative medicine and immunotherapy due to their unique biologic properties. In this …

A placebo-controlled, randomized trial of mesenchymal stem cells in COPD

DJ Weiss, R Casaburi, R Flannery, M LeRoux-Williams… - Chest, 2013 - Elsevier
Background COPD is a devastating disease affecting millions worldwide. As disease
pathogenesis includes both chronic pulmonary and systemic inflammation, antiinflammatory …

Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors

JW Lee, X Fang, A Krasnodembskaya, JP Howard… - Stem …, 2011 - academic.oup.com
Morbidity and mortality have declined only modestly in patients with clinical acute lung injury
(ALI) and acute respiratory distress syndrome (ARDS), despite extensive research into the …

Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes

I Guijarro-Muñoz, M Compte… - Journal of Biological …, 2014 - ASBMB
Pericytes and mesenchymal stem cells (MSCs) are ontogenically related, and in fact, no
significant phenotypic differences could be observed by flow cytometry. Transcriptome …

Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis

J Walter, LB Ware, MA Matthay - The Lancet Respiratory Medicine, 2014 - thelancet.com
Multipotent mesenchymal stem (stromal) cells (MSCs) have shown promising therapeutic
effects in preclinical models of both acute respiratory distress syndrome (ARDS) and sepsis …

Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action

L Ionescu, RN Byrne, T van Haaften… - … of Physiology-Lung …, 2012 - journals.physiology.org
Mortality and morbidity of acute lung injury and acute respiratory distress syndrome remain
high because of the lack of pharmacological therapies to prevent injury or promote repair …

Biomanufacturing for clinically advanced cell therapies

A Aijaz, M Li, D Smith, D Khong, C LeBlon… - Nature biomedical …, 2018 - nature.com
The achievements of cell-based therapeutics have galvanized efforts to bring cell therapies
to the market. To address the demands of the clinical and eventual commercial-scale …