The acute respiratory distress syndrome
MA Matthay, LB Ware… - The Journal of clinical …, 2012 - Am Soc Clin Investig
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory
failure that is often associated with multiple organ failure. Several clinical disorders can …
failure that is often associated with multiple organ failure. Several clinical disorders can …
Mesenchymal stem cells in tissue repair
AM DiMarino, AI Caplan, TL Bonfield - Frontiers in immunology, 2013 - frontiersin.org
The advent of mesenchymal stem cell (MSC)-based therapies for clinical therapeutics has
been an exciting and new innovation for the treatment of a variety of diseases associated …
been an exciting and new innovation for the treatment of a variety of diseases associated …
Intravenous infusion of human umbilical cord Wharton's jelly-derived mesenchymal stem cells as a potential treatment for patients with COVID-19 pneumonia
Y Zhang, J Ding, S Ren, W Wang, Y Yang, S Li… - Stem cell research & …, 2020 - Springer
The novel coronavirus disease 2019 (COVID-19) has grown to be a global public health
emergency since patients were first detected in Wuhan, China. Thus far, no specific drugs or …
emergency since patients were first detected in Wuhan, China. Thus far, no specific drugs or …
Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices
Mesenchymal stem cells (MSC s) have recently generated great interest in the fields of
regenerative medicine and immunotherapy due to their unique biologic properties. In this …
regenerative medicine and immunotherapy due to their unique biologic properties. In this …
A placebo-controlled, randomized trial of mesenchymal stem cells in COPD
DJ Weiss, R Casaburi, R Flannery, M LeRoux-Williams… - Chest, 2013 - Elsevier
Background COPD is a devastating disease affecting millions worldwide. As disease
pathogenesis includes both chronic pulmonary and systemic inflammation, antiinflammatory …
pathogenesis includes both chronic pulmonary and systemic inflammation, antiinflammatory …
Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors
JW Lee, X Fang, A Krasnodembskaya, JP Howard… - Stem …, 2011 - academic.oup.com
Morbidity and mortality have declined only modestly in patients with clinical acute lung injury
(ALI) and acute respiratory distress syndrome (ARDS), despite extensive research into the …
(ALI) and acute respiratory distress syndrome (ARDS), despite extensive research into the …
Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes
I Guijarro-Muñoz, M Compte… - Journal of Biological …, 2014 - ASBMB
Pericytes and mesenchymal stem cells (MSCs) are ontogenically related, and in fact, no
significant phenotypic differences could be observed by flow cytometry. Transcriptome …
significant phenotypic differences could be observed by flow cytometry. Transcriptome …
Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis
J Walter, LB Ware, MA Matthay - The Lancet Respiratory Medicine, 2014 - thelancet.com
Multipotent mesenchymal stem (stromal) cells (MSCs) have shown promising therapeutic
effects in preclinical models of both acute respiratory distress syndrome (ARDS) and sepsis …
effects in preclinical models of both acute respiratory distress syndrome (ARDS) and sepsis …
Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action
L Ionescu, RN Byrne, T van Haaften… - … of Physiology-Lung …, 2012 - journals.physiology.org
Mortality and morbidity of acute lung injury and acute respiratory distress syndrome remain
high because of the lack of pharmacological therapies to prevent injury or promote repair …
high because of the lack of pharmacological therapies to prevent injury or promote repair …
Biomanufacturing for clinically advanced cell therapies
The achievements of cell-based therapeutics have galvanized efforts to bring cell therapies
to the market. To address the demands of the clinical and eventual commercial-scale …
to the market. To address the demands of the clinical and eventual commercial-scale …