Antitarget, anti-SARS-CoV-2 leads, drugs, and the drug discovery–genetics alliance perspective
The most advanced antiviral molecules addressing major SARS-CoV-2 targets (Main
protease, Spike protein, and RNA polymerase), compared with proteins of other human …
protease, Spike protein, and RNA polymerase), compared with proteins of other human …
Advances in oxosulfonylation reaction
Oxosulfonylation is a difunctionalization protocol where oxo and sulfonyl groups are
introduced in one step to construct ketosulfones and N‐acylsulfonamides from simple and …
introduced in one step to construct ketosulfones and N‐acylsulfonamides from simple and …
Photo-induced stereo-and regiospecific sulfonylation of C–C multiple bonds exploiting the dual reactivity of sulfonium iodate (i) species
Vinyl sulfones are privileged motifs for assembling prevalent biologically active molecules
and represent “gateway functional groups” in medicinal chemistry and drug discovery …
and represent “gateway functional groups” in medicinal chemistry and drug discovery …
The fellowship of privileged scaffolds—One structure to inhibit them all
M Skoreński, M Sieńczyk - Pharmaceuticals, 2021 - mdpi.com
Over the past few years, the application of privileged structure has emerged as a powerful
approach to the discovery of new biologically active molecules. Privileged structures are …
approach to the discovery of new biologically active molecules. Privileged structures are …
Efficacy and safety of glecaprevir/pibrentasvir for chronic hepatitis C virus genotypes 1–6 infection: A systematic review and meta-analysis
This systematic review and meta-analysis investigated the efficacy and safety of glecaprevir
and pibrentasvir (G/P) for chronic hepatitis C virus (HCV) infection. Pubmed, Embase …
and pibrentasvir (G/P) for chronic hepatitis C virus (HCV) infection. Pubmed, Embase …
Controlled Synthesis of β‐Keto Sulfones and Vinyl Sulfones under Electrochemical Oxidation
Y Fang, D Xu, Y Yu, R Tang, S Dai… - European Journal of …, 2022 - Wiley Online Library
Selective sulfonylation and oxosulfonylation of alkenes with sulfinates have been developed
via anodic oxidation in an undivided cell. The novel electrosynthetic method provided β‐keto …
via anodic oxidation in an undivided cell. The novel electrosynthetic method provided β‐keto …
Dioxygen-triggered oxo-sulfonylation of hydrazones
A simple and highly efficient method for the oxo-sulfonylation of aldehyde-derived
hydrazones has been developed using sulfinic acid as a source of sulfonyl group and …
hydrazones has been developed using sulfinic acid as a source of sulfonyl group and …
Transition-Metal-Catalyzed Intermolecular C–H Carbonylation toward Amides
YL Li, ZY Gu, JB Xia - Synlett, 2021 - thieme-connect.com
The amide linkage is one of the most important structural moieties in both chemistry and
biology. Here, we briefly discuss recent advances in catalytic intermolecular C–H …
biology. Here, we briefly discuss recent advances in catalytic intermolecular C–H …
Palladium(0)-Catalyzed Carbonylative Synthesis of N-Acylsulfonamides via Regioselective Acylation
N-Acylsulfonamides represent an important bioisostere of carboxylic acids that allow for
greater molecular elaboration and enhanced hydrogen bonding capabilities. Herein, we …
greater molecular elaboration and enhanced hydrogen bonding capabilities. Herein, we …
[PDF][PDF] Beclabuvir can inhibit the RNA-dependent RNA polymerase of newly emerged novel coronavirus (SARS-CoV-2)
Recent emergence of novel coronavirus (SARS-CoV-2) in Wuhan, China has resulted more
than 14,510 global deaths. To date well-established therapeutics modules for infected …
than 14,510 global deaths. To date well-established therapeutics modules for infected …