A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …

Cell-fate decisions are controlled typically by conserved receptors that interact with co-
evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T …

An improved understanding of the anti-tumor CD8+ T cell response after checkpoint
blockade would enable more informed and effective therapeutic strategies. Here we …

An emerging approach for treating cancer involves programming patient-derived T cells with
genes encoding disease-specific chimeric antigen receptors (CARs), so that they can …

Stem-like CD8+ T cells are regulated by T cell factor 1 (TCF1) and are considered requisite
for immune checkpoint blockade (ICB) response. However, recent findings indicate that …

TCRαβ thymocytes differentiate into either CD8αβ+ cytotoxic T lymphocytes or CD4+ helper
T cells. This functional dichotomy is controlled by key transcription factors, including the …

Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-
stimulatory molecules to either undergo clonal deletion or to differentiate into specialized …

Following successful gene rearrangement at αβ T-cell receptor (TCR) loci, developing
thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection …

Recently, the transcription factor GATA-3 was shown to be selectively expressed in Th2 but
not Th1 cells and to augment Th2-specific cytokines. Here, we show that loss of GATA-3 …

Abstract TCRαβ+ CD3+ CD4− CD8−“double negative”(DN) T cells comprise a small subset
of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and …