Targeting micro-environmental pathways by PROTACs as a therapeutic strategy

J Liu, Y Peng, H Inuzuka, W Wei - Seminars in cancer biology, 2022 - Elsevier
Tumor microenvironment (TME) composes of multiple cell types and non-cellular
components, which supports the proliferation, metastasis and immune surveillance evasion …

Targeting PD-L1/PD-1-mediated inhibitory signaling with BTK inhibitors in Chronic Lymphocytic Leukemia (CLL).

MA Schwarzbich - 2020 - qmro.qmul.ac.uk
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults in the West. An
unmet need for equally curative and tolerable treatment approaches exists. Our group has …

Restoring Chimeric Antigen Receptor (CAR) T Cell Function in Chronic Lymphocytic Leukaemia (CLL

R Sanderson - 2020 - qmro.qmul.ac.uk
Differential outcomes for CD19 CAR T cells between chronic lymphocytic leukaemia,
lymphoma and acute lymphoblastic leukaemia illustrate unique challenges to overcome in …