Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …

Simple Summary The epithelial to mesenchymal transition (EMT) is a well-documented
process in the study of cancer metastases. The cytoskeleton is an intricate network involved …

Carcinoma cells residing in an intermediate phenotypic state along the epithelial–
mesenchymal (E–M) spectrum are associated with malignant phenotypes, such as …

Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their
stability, intrinsic mechanical properties, and cell type–specific expression patterns …

Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

Rationale: In obesity the fine-tuned balance of macrophage phenotypes is disturbed towards
a dominance of pro-inflammatory macrophages resulting in exacerbation and persistence of …

The keratin network of intermediate filaments provides keratinocytes with essential
mechanical strength and resilience, but the contribution to mechanosensing remains poorly …

Keratins are major components of the epithelial cytoskeleton and are believed to play a vital
role for mechanical integrity at the cellular and tissue level. Keratinocytes as the main cell …

The plakin family consists of giant proteins involved in the cross-linking and organization of
the cytoskeleton and adhesion complexes. They further modulate several fundamental …

Desmosomes are intercellular junctions that anchor intermediate filaments (IFs) to the
plasma membrane, forming a supracellular scaffold that provides mechanical resilience to …