Hydrophobic drugs exhibit altered bioavailability and pose other challenges at an industrial
level due to their poor solubility and dissolution rates. In addition, poor flowability …

Background and purpose: Kidney diseases impose significant global health challenges.
Potassium dichromate (PD) is a heavy metal frequently associated with nephrotoxicity. PD …

The application of Dunaliella salina (D. salina) microalgae in nutraceutical products is
limited due to poor aqueous solubility and consequently low bioavailability of the existing β …

The present study aimed to improve the neuroprotective effect of chrysin (CHR) by
combining two formulation techniques, phospholipid (PL) complexation and solid dispersion …

Flavoured functional effervescent powders are becoming increasingly popular by
consumers due to their health benefits and easy dissolution. In present study, orange …

Objective One of the main problems with NSAIDs is the dosing frequency, which leads to
patients' noncompliance. To overcome this, fabrication of sustained release formulation of …

Calcitriol, as the biologically active form of vitamin D3, is essential for patients with renal
osteopathy. The solubilization, stabilization, and content uniformity are key issues in its …

Anotace Předkládaná habilitační práce shrnuje dosavadní výsledky mé experimentální,
rešeršní a publikační činnosti v oblasti zvyšování rozpustnosti léčivých látek omezeně …