BACKGROUND The integrated stress response (ISR) is an evolutionarily conserved
intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable …

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite
for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular …

Background Obesity develops due to an imbalance in energy homeostasis, wherein energy
intake exceeds energy expenditure. Accumulating evidence shows that manipulations of …

Emotion plays a crucial role, both in general human experience and in psychiatric illnesses.
Despite the importance of emotion, the relative lack of objective methodologies to …

Cell signaling in response to an array of diverse stress stimuli converges on the
phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2). Phosphorylation of …

Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Choosing the right nutrients to consume is essential to health and wellbeing across species.
However, the factors that influence these decisions are poorly understood. This is …

Many cancer cells consume large quantities of glutamine to maintain TCA cycle anaplerosis
and support cell survival. It was therefore surprising when RNAi screening revealed that …

Drosophila melanogaster has been a key model in developing our current understanding of
the molecular mechanisms of ageing. Of particular note is its role in establishing the …

tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …