Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
A quantized mechanism for activation of pannexin channels
Abstract Pannexin 1 (PANX1) subunits form oligomeric plasma membrane channels that
mediate nucleotide release for purinergic signalling, which is involved in diverse …
mediate nucleotide release for purinergic signalling, which is involved in diverse …
Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes
EN Proshkina, MV Shaposhnikov… - Ageing Research …, 2015 - Elsevier
Drosophila is one of the most convenient model organisms in the genetics of aging and
longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by …
longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by …
Dronc-independent basal executioner caspase activity sustains Drosophila imaginal tissue growth
N Shinoda, N Hanawa, T Chihara… - Proceedings of the …, 2019 - National Acad Sciences
Caspase is best known as an enzyme involved in programmed cell death, which is
conserved among multicellular organisms. In addition to its role in cell death, caspase is …
conserved among multicellular organisms. In addition to its role in cell death, caspase is …
Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in Drosophila
In highly polarized neurons, an extensive endoplasmic reticulum (ER) network extends to
distal dendrites and axons. Several human diseases result from... The endoplasmic …
distal dendrites and axons. Several human diseases result from... The endoplasmic …
Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies
Protein chaperones play a critical role in proteostasis. The activity of the major endoplasmic
reticulum chaperone BiP (GRP78) is regulated by Fic-mediated AMPylation during resting …
reticulum chaperone BiP (GRP78) is regulated by Fic-mediated AMPylation during resting …
Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress
M Robin, AR Issa, CC Santos, F Napoletano… - Autophagy, 2019 - Taylor & Francis
The tumor suppressor TP53/p53 is a known regulator of apoptosis and macroautophagy/
autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently …
autophagy. However, the molecular mechanism by which TP53 regulates 2 apparently …
Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437
Cdk5 is a post-mitotic kinase with complex roles in maintaining neuronal health. The various
mechanisms by which Cdk5 inhibits and promotes neurodegeneration are still poorly …
mechanisms by which Cdk5 inhibits and promotes neurodegeneration are still poorly …
Exploring caspase-dependent non-lethal cellular processes using Drosophila
N Shinoda, M Miura - Frontiers in Cell Death, 2024 - frontiersin.org
Caspases are cysteine aspartic acid proteases conserved in animals that not only execute
apoptosis, but also regulate diverse cellular processes independent of apoptosis, which are …
apoptosis, but also regulate diverse cellular processes independent of apoptosis, which are …
ARC syndrome-linked Vps33B protein is required for inflammatory endosomal maturation and signal termination
Toll-like receptors (TLRs) and other pattern-recognition receptors (PRRs) sense microbial
ligands and initiate signaling to induce inflammatory responses. Although the quality of …
ligands and initiate signaling to induce inflammatory responses. Although the quality of …