Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

S Lalani, CL Poh - Viruses, 2020 - mdpi.com
Flavonoids are natural biomolecules that are known to be effective antivirals. These
biomolecules can act at different stages of viral infection, particularly at the molecular level to …

[HTML][HTML] COVID‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin

TC Theoharides - Biofactors (Oxford, England), 2020 - ncbi.nlm.nih.gov
Dear Editor The new coronavirus (severe acute pulmonary syndrome [SARS]-CoV-2)
originated in China, where it spread rapidly, 1 and has reached pandemic proportions …

A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19)

F Huang, Y Li, ELH Leung, X Liu, K Liu, Q Wang… - Pharmacological …, 2020 - Elsevier
The epidemic of pneumonia (COVID-19) caused by novel coronavirus (SARS-CoV-2)
infection has been listed as a public health emergency of international concern by the World …

COVID‐19, microthromboses, inflammation, and platelet activating factor

C Demopoulos, S Antonopoulou, TC Theoharides - Biofactors, 2020 - Wiley Online Library
Recent articles report elevated markers of coagulation, endothelial injury, and
microthromboses in lungs from deceased COVID‐19 patients. However, there has been no …

Quercetin: a functional food-flavonoid incredibly attenuates emerging and re-emerging viral infections through immunomodulatory actions

FM Shorobi, FY Nisa, S Saha, MAH Chowdhury… - Molecules, 2023 - mdpi.com
Many of the medicinally active molecules in the flavonoid class of phytochemicals are being
researched for their potential antiviral activity against various DNA and RNA viruses …

Flavonoids as promising antiviral agents against SARS-CoV-2 infection: a mechanistic review

MA Khazeei Tabari, A Iranpanah, R Bahramsoltani… - Molecules, 2021 - mdpi.com
A newly diagnosed coronavirus in 2019 (COVID-19) has affected all human activities since
its discovery. Flavonoids commonly found in the human diet have attracted a lot of attention …

Research progress of the antiviral bioactivities of natural flavonoids

L Wang, J Song, A Liu, B Xiao, S Li, Z Wen… - Natural products and …, 2020 - Springer
Flavonoids are now considered as an indispensable component in a variety of nutraceutical
and pharmaceutical applications. Most recent researches have focused on the health …

In silico and in vitro identification of pan-coronaviral main protease inhibitors from a large natural product library

N Shahhamzehei, S Abdelfatah, T Efferth - Pharmaceuticals, 2022 - mdpi.com
The main protease (Mpro or 3CLpro) in coronaviruses represents a promising specific drug
target as it is essential for the cleavage of the virus polypeptide and has a unique cleavage …

In silico bioprospecting of taraxerol as a main protease inhibitor of SARS-CoV-2 to develop therapy against COVID-19

S Mujwar, RK Harwansh - Structural Chemistry, 2022 - Springer
COVID-19 was caused by a novel coronavirus known as SARS-CoV-2. The COVID-19
disease outbreak has been avowed as a global pandemic by the World Health Organization …