Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …

Ever since lysozyme was discovered by Fleming in 1922, this protein has emerged as a
model for investigations on protein structure and function. Over the years, several high …

Single-walled carbon nanotubes (SWNTs) have been investigated for a variety of
applications including composite materials, electronics, and drug delivery. However, these …

In recent years, a great deal of interest has been focused on the development of novel
atomic force microscopy (AFM)-based methods. From first being an unstable method, AFM …

Parkinson's disease (PD) is a neurological disorder marked by the presence of cytoplasmic
inclusions, Lewy bodies (LBs) and Lewy neurites (LNs) as well as the degeneration of …

Recent advances in single molecule experiments have raised many challenges. These
challenges can be met by a proper understanding of the inter-and intra-molecular …

This paper describes protocols for studies of structure and dynamics of DNA and protein–
DNA complexes with atomic force microscopy (AFM) utilizing the surface chemistry …

The link between metals, Alzheimer's disease (AD) and its implicated protein, amyloid-β
(Aβ), is complex and highly studied. AD is believed to occur as a result of the misfolding and …

Surface preparation is a key step for reliable and reproducible imaging of DNA and protein-
DNA complexes with atomic force microscopy (AFM). This article describes the approaches …

Alzheimer's disease is linked to a pathological polymerization of the endogenous amyloid β-
peptide (Aβ) that ultimately forms amyloid plaques within the human brain. We used surface …