Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

Mitochondrial fission is a highly regulated process that, when disrupted, can alter
metabolism, proliferation and apoptosis,–. Dysregulation has been linked to …

Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

Abstract Purpose of Review Parkinson's disease (PD) is a complex neurodegenerative
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …

Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling
pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Antigen presentation is essential for establishing immune tolerance and for immune
responses against infectious disease and cancer. Although antigen presentation can be …