All Roads Lead to Cytosol: Trypanosoma cruzi Multi-Strategic Approach to Invasion

G Ferri, MM Edreira - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
T. cruzi has a complex life cycle involving four developmental stages namely, epimastigotes,
metacyclic trypomastigotes, amastigotes and bloodstream trypomastigotes. Although …

The parasitic intracellular lifestyle of trypanosomatids: parasitophorous vacuole development and survival

MF Batista, CA Nájera, I Meneghelli… - Frontiers in Cell and …, 2020 - frontiersin.org
The trypanosomatid (protozoan) parasites Trypanosoma cruzi and Leishmania spp. are
causative agents of Chagas disease and Leishmaniasis, respectively. They display high …

The Genome Sequence of Leishmania (Leishmania) amazonensis: Functional Annotation and Extended Analysis of Gene Models

F Real, RO Vidal, MF Carazzolle, JMC Mondego… - DNA …, 2013 - academic.oup.com
We present the sequencing and annotation of the Leishmania (Leishmania) amazonensis
genome, an etiological agent of human cutaneous leishmaniasis in the Amazon region of …

Amastin Knockdown in Leishmania braziliensis Affects Parasite-Macrophage Interaction and Results in Impaired Viability of Intracellular Amastigotes

RMC de Paiva, V Grazielle-Silva, MS Cardoso… - PLoS …, 2015 - journals.plos.org
Leishmaniasis, a human parasitic disease with manifestations ranging from cutaneous
ulcerations to fatal visceral infection, is caused by several Leishmania species. These …

A Brief View of the Surface Membrane Proteins from Trypanosoma cruzi

ÁC Pech-Canul, V Monteón… - Journal of Parasitology …, 2017 - Wiley Online Library
Trypanosoma cruzi is the causal agent of Chagas' disease which affects millions of people
around the world mostly in Central and South America. T. cruzi expresses a wide variety of …

BALB/c and C57BL/6 Mice Cytokine Responses to Trypanosoma cruzi Infection Are Independent of Parasite Strain Infectivity

BL Ferreira, ÉR Ferreira, MV De Brito, BR Salu… - Frontiers in …, 2018 - frontiersin.org
Trypanosoma cruzi is the etiologic agent of Chagas' disease, which affects 6–7 million
people worldwide. Different strains of T. cruzi present specific genotypic and phenotypic …

A systematic review of the Trypanosoma cruzi genetic heterogeneity, host immune response and genetic factors as plausible drivers of chronic chagasic …

P Jiménez, J Jaimes, C Poveda, JD Ramírez - Parasitology, 2019 - cambridge.org
Chagas disease is a complex tropical pathology caused by the kinetoplastid Trypanosoma
cruzi. This parasite displays massive genetic diversity and has been classified by …

Determinants of disease phenotype in trypanosomatid parasites

LI McCall, JH McKerrow - Trends in parasitology, 2014 - cell.com
Trypanosomatid parasites infect over 21 million people worldwide, with a range of disease
phenotypes. Trypanosoma cruzi causes American trypanosomiasis, wherein 30–40% of …

Impact of Laboratory-Adapted Intracellular Trypanosoma cruzi Strains on the Activity Profiles of Compounds with Anti-T. cruzi Activity

ML Sykes, EK Kennedy, VM Avery - Microorganisms, 2023 - mdpi.com
Chagas disease is caused by infection with the protozoan parasite, Trypanosoma cruzi. The
disease causes~ 12,000 deaths annually and is one of the world's 20 neglected tropical …

Modulation of Virulence Factors during Trypanosoma cruzi Differentiation

C Oliveira, FB Holetz, LR Alves, AR Ávila - Pathogens, 2022 - mdpi.com
Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi. This
protozoan developed several mechanisms to infect, propagate, and survive in different …