Abstract mTOR (mammalian target of rapamycin), which is a serine/threonine kinase, has
been well-established as being closely correlated with the occurrence of various human …

The mechanistic/mammalian target of rapamycin (mTOR), also known as the mechanistic
target of rapamycin, regulates many normal cell processes such as transcription, cell growth …

Two series of novel morpholinopyrimidine derivatives were synthesized and screened for
their in-vitro cytotoxic activity against 60 tumor cell line by the National Cancer Institute, USA …

Abstract C-5 Substituted pyrido [3, 2-e] tetrazolo [1, 5-a] pyrimidines were obtained by simple
azidation of 2, 4-dichloropyrido [2, 3-d] pyrimidine followed by SN Ar reactions with S-, N …

Prostate cancer (PC) is one of the most common types of cancer in males. Although early
stages of PC are generally associated with favorable outcomes, advanced phases of the …

The dual PI3Kα/m TOR inhibitors represent a promising molecularly targeted therapy for
cancer. Here, we documented the discovery of new 2, 4-disubstituted quinazoline analogs …

Aim: Novel thiazole hybrids were synthesized via thiazolation of 4-phenylthiosemicarbazone
(4). Materials & methods: The anticancer activity against the NCI 60 cancer cell line panel …

The development of anticancer drugs targeting both PI3K and mTOR pathways is
recognized as a promising cancer therapeutic approach. In the current study we designed …

Due to the limitations of existing anti-EV71 targets, we have been eager to discover a new
anti-EV71 agent based on mTOR (the mammalian target of rapamycin), which is an …

Abstract Using pyridino [2, 3-D] pyrimidine as the core, total 13 pyridino [2, 3-D] pyrimidine
derivatives with different alkyl substituents at C2 site have been designed and synthesized …