Genome control by SMC complexes

C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

[HTML][HTML] Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project

J Dekker, F Alber, S Aufmkolk, BJ Beliveau… - Molecular cell, 2023 - cell.com
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …

Condensed but liquid-like domain organization of active chromatin regions in living human cells

T Nozaki, S Shinkai, S Ide, K Higashi, S Tamura… - Science …, 2023 - science.org
In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …

scNanoHi-C: a single-cell long-read concatemer sequencing method to reveal high-order chromatin structures within individual cells

W Li, J Lu, P Lu, Y Gao, Y Bai, K Chen, X Su, M Li… - Nature …, 2023 - nature.com
The high-order three-dimensional (3D) organization of regulatory genomic elements
provides a topological basis for gene regulation, but it remains unclear how multiple …

All eukaryotic SMC proteins induce a twist of− 0.6 at each DNA loop extrusion step

R Janissen, R Barth, IF Davidson, JM Peters… - Science …, 2024 - science.org
Eukaryotes carry three types of structural maintenance of chromosome (SMC) protein
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …

Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation

JH Yang, AS Hansen - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

YY1-controlled regulatory connectivity and transcription are influenced by the cell cycle

JC Lam, NG Aboreden, SC Midla, S Wang, A Huang… - Nature Genetics, 2024 - nature.com
Few transcription factors have been examined for their direct roles in physically connecting
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …

Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries

LH Chang, S Ghosh, A Papale, JM Luppino… - Nature …, 2023 - nature.com
Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …

Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome

DB Brückner, H Chen, L Barinov, B Zoller, T Gregor - Science, 2023 - science.org
Chromosomes in the eukaryotic nucleus are highly compacted. However, for many
functional processes, including transcription initiation, the pairwise motion of distal …

TADs: Dynamic structures to create stable regulatory functions

JA da Costa-Nunes, D Noordermeer - Current Opinion in Structural Biology, 2023 - Elsevier
Mammalian chromosomes are organized at different length scales within the cell nucleus.
Topologically Associating Domains (TADs) are structural units of 3D genome organization …