Genome control by SMC complexes
C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
[HTML][HTML] Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …
and the nucleus in space and time. We summarize progress by the consortium and highlight …
Condensed but liquid-like domain organization of active chromatin regions in living human cells
In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …
domains, for various cellular functions. However, their physical nature in living cells remains …
scNanoHi-C: a single-cell long-read concatemer sequencing method to reveal high-order chromatin structures within individual cells
The high-order three-dimensional (3D) organization of regulatory genomic elements
provides a topological basis for gene regulation, but it remains unclear how multiple …
provides a topological basis for gene regulation, but it remains unclear how multiple …
All eukaryotic SMC proteins induce a twist of− 0.6 at each DNA loop extrusion step
Eukaryotes carry three types of structural maintenance of chromosome (SMC) protein
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation
The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …
defined as DNA sequences that can activate transcription at promoters in an orientation …
YY1-controlled regulatory connectivity and transcription are influenced by the cell cycle
Few transcription factors have been examined for their direct roles in physically connecting
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …
enhancers and promoters. Here acute degradation of Yin Yang 1 (YY1) in erythroid cells …
Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries
Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome
Chromosomes in the eukaryotic nucleus are highly compacted. However, for many
functional processes, including transcription initiation, the pairwise motion of distal …
functional processes, including transcription initiation, the pairwise motion of distal …
TADs: Dynamic structures to create stable regulatory functions
JA da Costa-Nunes, D Noordermeer - Current Opinion in Structural Biology, 2023 - Elsevier
Mammalian chromosomes are organized at different length scales within the cell nucleus.
Topologically Associating Domains (TADs) are structural units of 3D genome organization …
Topologically Associating Domains (TADs) are structural units of 3D genome organization …