Applications of multi‐omics analysis in human diseases
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …
Integrative metabolomics science in Alzheimer's disease: relevance and future perspectives
Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …
Open access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics
Despite the increasing availability of tandem mass spectrometry (MS/MS) community
spectral libraries for untargeted metabolomics over the past decade, the majority of acquired …
spectral libraries for untargeted metabolomics over the past decade, the majority of acquired …
Branched-chain amino acids are linked with Alzheimer's disease-related pathology and cognitive deficits
MAB Siddik, CA Mullins, A Kramer, H Shah… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder with a complex
pathophysiology. Type 2 diabetes (T2D) is a strong risk factor for AD that shares similar …
pathophysiology. Type 2 diabetes (T2D) is a strong risk factor for AD that shares similar …
Intermittent fasting protects against Alzheimer's disease in mice by altering metabolism through remodeling of the gut microbiota
RY Pan, J Zhang, J Wang, Y Wang, Z Li, Y Liao, Y Liao… - Nature Aging, 2022 - nature.com
Alzheimer's disease (AD) is the most common form of dementia without effective clinical
treatment. Here, we show that intermittent fasting (IF) improves cognitive functions and AD …
treatment. Here, we show that intermittent fasting (IF) improves cognitive functions and AD …
Omics-based biomarkers discovery for Alzheimer's disease
Q Aerqin, ZT Wang, KM Wu, XY He, Q Dong… - Cellular and Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
Effects of a ketogenic and low‐fat diet on the human metabolome, microbiome, and foodome in adults at risk for Alzheimer's disease
INTRODUCTION The ketogenic diet (KD) is an intriguing therapeutic candidate for
Alzheimer's disease (AD) given its protective effects against metabolic dysregulation and …
Alzheimer's disease (AD) given its protective effects against metabolic dysregulation and …
Status of metabolomic measurement for insights in Alzheimer's disease progression—What is missing?
Alzheimer's disease (AD) is an aging-related neurodegenerative disease, leading to the
progressive loss of memory and other cognitive functions. As there is still no cure for AD, the …
progressive loss of memory and other cognitive functions. As there is still no cure for AD, the …
Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites
Background Blood-derived mitochondrial DNA copy number (mtDNA-CN) is a proxy
measurement of mitochondrial function in the peripheral and central systems. Abnormal …
measurement of mitochondrial function in the peripheral and central systems. Abnormal …
Identification of key lipid metabolism-related genes in Alzheimer's disease
Background Alzheimer's disease (AD) represents profound degenerative conditions of the
brain that cause significant deterioration in memory and cognitive function. Despite …
brain that cause significant deterioration in memory and cognitive function. Despite …