mTOR signaling disruption and its association with the development of autism spectrum disorder
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by impairments in social interaction and communication along with repetitive stereotypic …
by impairments in social interaction and communication along with repetitive stereotypic …
Epileptogenesis in tuberous sclerosis complex-related developmental and epileptic encephalopathy
E Aronica, N Specchio, MJ Luinenburg, P Curatolo - Brain, 2023 - academic.oup.com
Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …
Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex
While shaped and constrained by axonal connections, fMRI-based functional connectivity
reorganizes in response to varying interareal input or pathological perturbations. However …
reorganizes in response to varying interareal input or pathological perturbations. However …
Whole-brain comparison of rodent and human brains using spatial transcriptomics
A Beauchamp, Y Yee, BC Darwin, A Raznahan… - Elife, 2022 - elifesciences.org
The ever-increasing use of mouse models in preclinical neuroscience research calls for an
improvement in the methods used to translate findings between mouse and human brains …
improvement in the methods used to translate findings between mouse and human brains …
Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience …
The salience network (SN) and default mode network (DMN) play a crucial role in cognitive
function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to …
function. The SN, anchored in the anterior insular cortex (AI), has been hypothesized to …
Mapping and comparing fMRI connectivity networks across species
M Pagani, D Gutierrez‐Barragan… - Communications …, 2023 - nature.com
Technical advances in neuroimaging, notably in fMRI, have allowed distributed patterns of
functional connectivity to be mapped in the human brain with increasing spatiotemporal …
functional connectivity to be mapped in the human brain with increasing spatiotemporal …
Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli
The default mode network (DMN) is critical for self-referential mental processes, and its
dysfunction is implicated in many neuropsychiatric disorders. However, the …
dysfunction is implicated in many neuropsychiatric disorders. However, the …
Functional connectivity of the brain across rodents and humans
N Xu, TJ LaGrow, N Anumba, A Lee, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the
spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is …
spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is …
The synaptic and circuit functions of vitamin D in neurodevelopment disorders
X Ye, Q Zhou, P Ren, W Xiang… - … Disease and Treatment, 2023 - Taylor & Francis
Vitamin D deficiency/insufficiency is a public health issue around the world. According to
epidemiological studies, low vitamin D levels have been associated with an increased risk of …
epidemiological studies, low vitamin D levels have been associated with an increased risk of …
Advances in the mTOR signaling pathway and its inhibitor rapamycin in epilepsy
W Zhao, C Xie, X Zhang, J Liu, J Liu… - Brain and Behavior, 2023 - Wiley Online Library
Introduction Epilepsy is one of the most common and serious brain syndromes and has
adverse consequences on a patient's neurobiological, cognitive, psychological, and social …
adverse consequences on a patient's neurobiological, cognitive, psychological, and social …