[HTML][HTML] Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
[HTML][HTML] Blood-brain barrier: from physiology to disease and back
MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …
pathogens from entering the brain. At the same time, the BBB regulates transport of …
[HTML][HTML] Early-onset Alzheimer's disease: what is missing in research?
Abstract Purpose of Review Early-onset Alzheimer's disease (EOAD), defined as
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …
Pericytes of the neurovascular unit: key functions and signaling pathways
MD Sweeney, S Ayyadurai, BV Zlokovic - Nature neuroscience, 2016 - nature.com
Pericytes are vascular mural cells embedded in the basement membrane of blood
microvessels. They extend their processes along capillaries, pre-capillary arterioles and …
microvessels. They extend their processes along capillaries, pre-capillary arterioles and …
Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
Risk factors associated with the onset and progression of Alzheimer's disease: A systematic review of the evidence
M Hersi, B Irvine, P Gupta, J Gomes, N Birkett… - Neurotoxicology, 2017 - Elsevier
A systematic review was conducted to identify risk factors associated with the onset and
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …
Microglial phagocytosis: a disease-associated process emerging from Alzheimer's disease genetics
Alzheimer's disease (AD) is a debilitating, chronic neurodegenerative disease. Genetic
studies involving genome-wide association studies (GWAS) and meta-analysis have …
studies involving genome-wide association studies (GWAS) and meta-analysis have …
[HTML][HTML] Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional …
Abstract The Alzheimer's Disease Sequencing Project (ADSP) undertook whole exome
sequencing in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal …
sequencing in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal …
Genes associated with Alzheimer's disease: an overview and current status
M Giri, M Zhang, Y Lü - Clinical interventions in aging, 2016 - Taylor & Francis
Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …
common form of dementia in elderly people. It is an emerging public health problem that …
Epidemiology of Alzheimer disease
The global prevalence of dementia has been estimated to be as high as 24 million, and is
predicted to double every 20 years until at least 2040. As the population worldwide …
predicted to double every 20 years until at least 2040. As the population worldwide …