Pharmacology and therapeutics of bronchodilators revisited

MG Matera, CP Page, L Calzetta, P Rogliani… - Pharmacological …, 2020 - Elsevier
Bronchodilators remain the cornerstone of the treatment of airway disorders such as asthma
and chronic obstructive pulmonary disease (COPD). There is therefore considerable interest …

Regulators of A20 (TNFAIP3): new drug-able targets in inflammation

G Momtazi, BN Lambrecht… - American Journal of …, 2019 - journals.physiology.org
Persistent activation of the transcription factor Nuclear factor-κB (NF-κB) is central to the
pathogenesis of many inflammatory disorders, including those of the lung such as cystic …

Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor‐κB inflammatory signaling pathway in human skin cells

MO Altonsy, HA Kurwa, GJ Lauzon… - Immunity …, 2020 - Wiley Online Library
Introduction Corynebacterium tuberculostearicum (C. t.) is a ubiquitous bacterium that
colonizes human skin. In contrast to other members of the genus Corynebacterium, such as …

Effect of fracture risk in inhaled corticosteroids in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

S Peng, C Tan, L Du, Y Niu, X Liu, R Wang - BMC Pulmonary Medicine, 2023 - Springer
Background The fracture risk of patients with chronic obstructive pulmonary disease (COPD)
treated with inhaled corticosteroids is controversial. And some large-scale randomized …

Insights into glucocorticoid responses derived from omics studies

M Kan, BE Himes - Pharmacology & therapeutics, 2021 - Elsevier
Glucocorticoid drugs are commonly used in the treatment of several conditions, including
autoimmune diseases, asthma and cancer. Despite their widespread use and knowledge of …

Important lessons learned from studies on the pharmacology of glucocorticoids in human airway smooth muscle cells: Too much of a good thing may be a problem

Y Amrani, RA Panettieri, P Ramos-Ramirez… - Pharmacology & …, 2020 - Elsevier
Glucocorticoids (GCs) are the treatment of choice for chronic inflammatory diseases such as
asthma. Despite proven effective anti-inflammatory and immunosuppressive effects, long …

Daily Eicosapentaenoic Acid Infusion in IUGR Fetal Lambs Reduced Systemic Inflammation, Increased Muscle ADRβ2 Content, and Improved Myoblast Function and …

HN Beer, TA Lacey, RL Gibbs, MS Most, ZM Hicks… - Metabolites, 2024 - mdpi.com
Intrauterine growth-restricted (IUGR) fetuses exhibit systemic inflammation that contributes to
programmed deficits in myoblast function and muscle growth. Thus, we sought to determine …

[HTML][HTML] Elevated Fracture Risks in Patients Using Inhaled Corticosteroids: A Korean Nationwide Study

SH Kong, AJ Jo, CM Park, KI Park, JE Yun… - Endocrinology and …, 2024 - e-enm.org
Background In this comprehensive retrospective nationwide cohort study, we examined the
relationships between various asthma medications and bone health, utilizing data from the …

Modulation of allergic inflammation in the lung by a peptide derived from Mycobacteria tuberculosis chaperonin 60.1

Y Riffo‐Vasquez, V Kanabar, SD Keir… - Clinical & …, 2020 - Wiley Online Library
Background We have previously demonstrated that Mycobacteria tuberculosis chaperonin
60.1 inhibits leucocyte diapedesis and bronchial hyperresponsiveness in a murine model of …

TNF-α and Poly (I: C) induction of A20 and activation of NF-κB signaling are independent of ABCF1 in human airway epithelial cells

QT Cao, M Ishak, I Shpilman, JA Hirota - Scientific Reports, 2023 - nature.com
ABCF1 is the most characterized member of the ABCF family in eukaryotes with proposed
functions related to innate immunity in fibroblasts, macrophages, and epithelial cells …