Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance

JJ Pestka - Archives of toxicology, 2010 - Springer
The trichothecene mycotoxin deoxynivalenol (DON) is produced in wheat, barley and corn
following infestation by the fungus Fusarium in the field and during storage. Colloquially …

Deoxynivalenol: Mechanisms of action and its effects on various terrestrial and aquatic species

JM Hooft, DP Bureau - Food and Chemical Toxicology, 2021 - Elsevier
Deoxynivalenol, a type B trichothecene mycotoxin produced by Fusarium species of fungi, is
a ubiquitious contaminant of cereal grains worldwide. Chronic, low dose consumption of …

Deoxynivalenol-induced proinflammatory gene expression: mechanisms and pathological sequelae

JJ Pestka - Toxins, 2010 - mdpi.com
The trichothecene mycotoxin deoxynivalenol (DON) is commonly encountered in human
cereal foods throughout the world as a result of infestation of grains in the field and in …

Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol

J Pestka - World Mycotoxin Journal, 2010 - wageningenacademic.com
Produced by the mould genus Fusarium, the type B trichothecenes include deoxynivalenol
(DON), nivalenol (NIV) and their acetylated precursors. These mycotoxins often contaminate …

Deoxynivalenol, gut microbiota and immunotoxicity: A potential approach?

Y Liao, Z Peng, L Chen, AK Nüssler, L Liu… - Food and Chemical …, 2018 - Elsevier
Deoxynivalenol (DON, vomitoxin) is the most frequent mycotoxin in grains and grain
products. DON contamination in fodder and food is a serious threat for health, since it …

Trichothecene toxicity in eukaryotes: Cellular and molecular mechanisms in plants and animals

C Arunachalam, FM Doohan - Toxicology letters, 2013 - Elsevier
Trichothecenes are sesquiterpenoid mycotoxins commonly found as contaminants in cereal
grains and are a major health and food safety concern due to their toxicity to humans and …

Deoxynivalenol (DON)-Triggered Dual-Color Composite Probe Based on Gold Nanoclusters for Simultaneous Imaging of DON and miR-34a in Living Cells

W Yu, L Kang, X Lin, N Duan, D Ying, Z Wang… - Analytical …, 2023 - ACS Publications
Deoxynivalenol (DON) is a mycotoxin secreted by Fusarium species, posing great harm to
food safety and human health. Therefore, it is of great significance to study its toxic effects …

Dynamic changes in ribosome-associated proteome and phosphoproteome during deoxynivalenol-induced translation inhibition and ribotoxic stress

X Pan, DA Whitten, CG Wilkerson… - toxicological …, 2014 - academic.oup.com
Deoxynivalenol (DON), a trichothecene mycotoxin produced by Fusarium that commonly
contaminates cereal-based food, interacts with the ribosome to cause translation inhibition …

Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage

X Pan, DA Whitten, M Wu, C Chan… - Toxicology and applied …, 2013 - Elsevier
Deoxynivalenol (DON), a trichothecene mycotoxin produced by Fusarium that commonly
contaminates food, is capable of activating mononuclear phagocytes of the innate immune …

Deoxynivalenol downregulates NRF2-induced cytoprotective response in human hepatocellular carcinoma (HepG2) cells

S Ndlovu, S Nagiah, NS Abdul, T Ghazi… - Toxicon, 2021 - Elsevier
Deoxynivalenol (DON) commonly infects agricultural foods; it exhibits toxicity by inducing
oxidative stress and inhibiting protein synthesis. Nuclear factor erythroid 2-related factor 2 …