G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …

In the present article the putative role of environmental factors in schizophrenia is reviewed
and synthesized. Accumulating evidence from recent studies suggests that environmental …

Background The tremendous clinical and aetiological diversity among individuals with
autism spectrum disorder (ASD) has been a major obstacle to the development of new …

Understanding the organization of the cerebral cortex remains a central focus of
neuroscience. Cortical maps have relied almost exclusively on the examination of …

Genes are major contributors to many psychiatric diseases, but their mechanisms of action
have long seemed elusive. The intermediate phenotype concept represents a strategy for …

Concern is building about high rates of schizophrenia in large cities, and among immigrants,
cannabis users, and traumatized individuals, some of which likely reflects the causal …

Personality neuroscience involves the use of neuroscience methods to study individual
differences in behavior, motivation, emotion, and cognition. Personality psychology has …

Many of the major neuropsychiatric illnesses, including schizophrenia, have a typical age of
onset in late adolescence. Late adolescence may reflect a critical period in brain …

Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date …

Genetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for
prefrontal dopamine flux, has been studied extensively using both behavioral and …