The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …
review, the different subtypes of voltage-gated calcium channels are described and their …
Voltage-gated calcium channels
WA Catterall - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …
changes into intracellular Ca2+ transients that initiate many physiological events. There are …
CaMKII: claiming center stage in postsynaptic function and organization
JW Hell - Neuron, 2014 - cell.com
While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …
recent work points to new dimensions of CaMKII function in the nervous system, revealing …
Excitation–transcription coupling, neuronal gene expression and synaptic plasticity
Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …
[HTML][HTML] CaV1 and CaV2 channels engage distinct modes of Ca2+ signaling to control CREB-dependent gene expression
Activity-dependent gene expression triggered by Ca 2+ entry into neurons is critical for
learning and memory, but whether specific sources of Ca 2+ act distinctly or merely supply …
learning and memory, but whether specific sources of Ca 2+ act distinctly or merely supply …
L‐type Ca2+ channels in heart and brain
J Striessnig, A Pinggera, G Kaur… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …
Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function
S Erdogmus, AR Concepcion, M Yamashita… - Nature …, 2022 - nature.com
TCR stimulation triggers Ca2+ signals that are critical for T cell function and immunity.
Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) …
Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) …
The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation
PSB Finnie, K Nader - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
Memory allows organisms to predict future events based on prior experiences. This requires
encoded information to persist once important predictors are extracted, while also being …
encoded information to persist once important predictors are extracted, while also being …
The auditory hair cell ribbon synapse: from assembly to function
S Safieddine, A El-Amraoui… - Annual review of …, 2012 - annualreviews.org
Cochlear inner hair cells (IHCs), the mammalian auditory sensory cells, encode acoustic
signals with high fidelity by Graded variations of their membrane potential trigger rapid and …
signals with high fidelity by Graded variations of their membrane potential trigger rapid and …
A novel human CAMK2A mutation disrupts dendritic morphology and synaptic transmission, and causes ASD-related behaviors
Characterizing the functional impact of novel mutations linked to autism spectrum disorder
(ASD) provides a deeper mechanistic understanding of the underlying pathophysiological …
(ASD) provides a deeper mechanistic understanding of the underlying pathophysiological …