Clinical observations and experimental studies have determined that systemic acid-base
disturbances can profoundly affect the heart. A wealth of information is available on the …

methylglutaric (3MG) acid is a conspicuous C6 dicarboxylic organic acid classically
associated with two distinct leucine pathway enzyme deficiencies. 3MG acid is excreted in …

Short-term fasting is beneficial for the regeneration of multiple tissue types. However, the
effects of fasting on muscle regeneration are largely unknown. Here, we report that fasting …

Several genetic discoveries robustly implicate five single-nucleotide variants in the
progression of non-alcoholic fatty liver disease to non-alcoholic steatohepatitis and fibrosis …

As heart failure develops, the heart utilizes ketone bodies at increased rates, indicating an
adaptive stress response. Thus, increasing ketone body availability exerts protective effects …

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological
processes in health and disease. A detailed, integrative single-view description of how the …

Summary The Russian dandelion Taraxacum koksaghyz synthesizes considerable amounts
of high‐molecular‐weight rubber in its roots. The characterization of factors that participate …

In a field where even experts may find that years have elapsed since they last encountered a
child with a given disorder, it is essential for the clinician to have a comprehensive source of …

Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency (HMGCLD) is a rare inborn error of
ketone body synthesis and leucine degradation, caused by mutations in the HMGCL gene …

Ketone bodies acetoacetate and 3-hydroxy-n-butyric acid are metabolites derived from fatty
acids and ketogenic amino acids such as leucine. They are mainly produced in the liver via …