Recent advances and perspectives on production of value-added organic acids through metabolic engineering

H Liu, Y Jin, R Zhang, Y Ning, Y Yu, P Xu, L Deng… - Biotechnology …, 2023 - Elsevier
Organic acids are important consumable materials with a wide range of applications in the
food, biopolymer and chemical industries. The global consumer organic acids market is …

Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: advances and prospects

X Yin, J Li, H Shin, G Du, L Liu, J Chen - Biotechnology advances, 2015 - Elsevier
Organic acids, which are chemically synthesized, are also natural intermediates in the
metabolic pathways of microorganisms, among which the tricarboxylic acid (TCA) cycle is …

DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals

X Chen, C Gao, L Guo, G Hu, Q Luo, J Liu… - Chemical …, 2018 - ACS Publications
Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …

Highly efficient neutralizer-free l-malic acid production using engineered Saccharomyces cerevisiae

L Sun, Q Zhang, X Kong, Y Liu, J Li, G Du, X Lv… - Bioresource …, 2023 - Elsevier
In industrial bioproduction of organic acids, numerous neutralizers are required which
substantially increases production costs and burdens the environment. To address this …

Construction of reductive pathway in Saccharomyces cerevisiae for effective succinic acid fermentation at low pH value

D Yan, C Wang, J Zhou, Y Liu, M Yang, J Xing - Bioresource technology, 2014 - Elsevier
Succinic acid is an important precursor for the synthesis of high-value-added products.
Saccharomyces cerevisiae is a suitable platform for succinic acid production because of its …

Anaerobic fermentation for production of carboxylic acids as bulk chemicals from renewable biomass

J Wang, M Lin, M Xu, ST Yang - Anaerobes in biotechnology, 2016 - Springer
Biomass represents an abundant carbon-neutral renewable resource which can be
converted to bulk chemicals to replace petrochemicals. Carboxylic acids have wide …

Current advance in biological production of short-chain organic acid

L Sun, M Gong, X Lv, Z Huang, Y Gu, J Li, G Du… - Applied Microbiology …, 2020 - Springer
As natural metabolites, organic acids have been widely applied in food, pharmaceutical, and
bio-based materials industries. Particularly, the short-chain organic acids, including C2, C3 …

Protein and metabolic engineering for the production of organic acids

J Liu, J Li, H Shin, L Liu, G Du, J Chen - Bioresource Technology, 2017 - Elsevier
Organic acids are natural metabolites of living organisms. They have been widely applied in
the food, pharmaceutical, and bio-based materials industries. In recent years …

Bioproduction of fumaric acid: An insight into microbial strain improvement strategies

J Sebastian, K Hegde, P Kumar, T Rouissi… - Critical reviews in …, 2019 - Taylor & Francis
Fumaric acid (FA), a metabolic intermediate, has been identified as an important
carbohydrate derived platform chemical. Currently, it is commercially sourced from …

Non-Saccharomyces as Biotools to Control the Production of Off-Flavors in Wines

A Morata, I Loira, C González, C Escott - Molecules, 2021 - mdpi.com
Off-flavors produced by undesirable microbial spoilage are a major concern in wineries, as
they affect wine quality. This situation is worse in warm areas affected by global warming …