Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal
gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of …

Insomnia is a serious worldwide health threat, affecting nearly one third of the general
population. Melatonin has been reported to improve sleep efficiency and it was found that …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

Currently, in developed countries, nights are excessively illuminated (light at night), whereas
daytime is mainly spent indoors, and thus people are exposed to much lower light intensities …

Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

Glucocorticoids, hormones produced by the adrenal gland cortex, exert numerous functions
in body homeostasis and the response of the organism to external stressors. One striking …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks
found throughout the body coordinate circadian rhythms of behavior and physiology. We …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

Brain aging is linked to certain types of neurodegenerative diseases and identifying new
therapeutic targets has become critical. Melatonin, a pineal hormone, associates with …