The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …

Coronaviruses (CoVs) are enveloped positive-stranded RNA viruses with spike (S) protein
projections that allow the virus to enter and infect host cells. The S protein is a key virulence …

The 3C-like protease (3CLpro) of severe acute respiratory syndrome-associated coronavirus
(SARS-CoV) is one of the most promising targets for discovery of drugs against SARS …

Severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (Mpro), a
protein required for the maturation of SARS-CoV, is vital for its life cycle, making it an …

Background/Aims The efficacies of lopinavir-ritonavir or hydroxychloroquine remain to be
determined in patients with coronavirus disease 2019 (COVID-19). To compare the …

Feline infectious peritonitis (FIP) is a fatal disease in domestic and nondomestic felids
caused by feline coronavirus (FCoV). Currently, no effective vaccine is available for the …

Coronaviruses are important human and animal pathogens of the order Nidovirales. Several
new members were discovered following the emergence of SARS-CoV in human …

Computational chemistry has always played a key role in anti-viral drug development. The
challenges and the quickly rising public interest when a virus is becoming a threat has …

With the breakthrough crystallization of the bacterial leucine transporter protein LeuT, the
first available X-ray structure for the neurotransmitter/sodium symporter family, development …

The coronavirus main protease, Mpro, is considered to be a major target for drugs suitable
for combating coronavirus infections including severe acute respiratory syndrome (SARS) …