Pseudomonas aeruginosa is a Gram-negative bacterium belonging to the γ-proteobacteria.
Like other members of the Pseudomonas genus, it is known for its metabolic versatility and …

We have become increasingly aware that, during infection, pathogenic bacteria often grow
in multicellular biofilms that are often highly resistant to antibacterial strategies. In order to …

Defining the essential genome of bacterial pathogens is central to developing an
understanding of the biological processes controlling disease. This has proven elusive for …

Bacteria are now generally believed to adopt two main lifestyles: planktonic individuals, or
surface-attached biofilms. However, in recent years medical microbiologists started to stress …

There is growing concern about the relevance of in vitro antimicrobial susceptibility tests
when applied to isolates of P. aeruginosa from cystic fibrosis (CF) patients. Existing methods …

Bacterial biofilms can be found in most environments on our planet, and the human body is
no exception. Consisting of microbial cells encased in a matrix of extracellular polymers …

Bacterial chitinases (EC 3.2. 1.14) and chitin-binding proteins (CBPs) play a fundamental
role in the degradation of the ubiquitous biopolymer chitin, and the degradation products …

Adaptation is likely to be an important determinant of the success of many pathogens, for
example when colonizing a new host species, when challenged by antibiotic treatment, or in …

Biofilm-associated infections are difficult to treat and eradicate because of their increased
antimicrobial tolerance. In vitro biofilm models have enabled the high throughput testing of …

The minimal inhibitory concentration (MIC) assay uses agar or broth dilution methods to
measure, under defined test conditions, the lowest effective concentration of an antimicrobial …