Pharmacologically aware phage therapy: pharmacodynamic and pharmacokinetic obstacles to phage antibacterial action in animal and human bodies

K Dąbrowska, ST Abedon - Microbiology and Molecular Biology …, 2019 - Am Soc Microbiol
The use of viruses infecting bacteria (bacteriophages or phages) to treat bacterial infections
has been ongoing clinically for approximately 100 years. Despite that long history, the …

Bacteriophage production processes

K Jurač, D Nabergoj, A Podgornik - Applied microbiology and …, 2019 - Springer
High quantities of bacteriophages are currently used in the food industry and agriculture.
However, growing antibiotic resistance of bacteria has recently awakened the interest to use …

Modified bacteriophage S16 long tail fiber proteins for rapid and specific immobilization and detection of Salmonella cells

JM Denyes, M Dunne, S Steiner… - Applied and …, 2017 - Am Soc Microbiol
Bacteriophage-based assays and biosensors rival traditional antibody-based
immunoassays for detection of low-level Salmonella contaminations. In this study, we …

Temporal dynamics of the early immune response following Mycobacterium bovis infection of cattle

T Holder, S Srinivasan, A McGoldrick, GA Williams… - Scientific reports, 2024 - nature.com
Bovine tuberculosis is an infectious disease of global significance that remains endemic in
many countries. Mycobacterium bovis infection in cattle is characterized by a cell-mediated …

Cellular reagents for diagnostics and synthetic biology

S Bhadra, A Pothukuchy, R Shroff, AW Cole, M Byrom… - PLoS …, 2018 - journals.plos.org
We have found that the overproduction of enzymes in bacteria followed by their
lyophilization leads to'cellular reagents' that can be directly used to carry out numerous …

Rapid detection of viable Bacillus anthracis spores in environmental samples by using engineered reporter phages

NJ Sharp, IJ Molineux, MA Page… - Applied and …, 2016 - Am Soc Microbiol
Bacillus anthracis, the causative agent of anthrax, was utilized as a bioterrorism agent in
2001 when spores were distributed via the US postal system. In responding to this event, the …

Effect of dilution rate on productivity of continuous bacteriophage production in cellstat

D Nabergoj, N Kuzmić, B Drakslar… - Applied microbiology and …, 2018 - Springer
Ability to efficiently propagate high quantities of bacteriophages (phages) is of great
importance considering higher phage production needs in the future. Continuous production …