Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons
The main breakthrough in tumor immunotherapy was the discovery of immune checkpoint
(IC) proteins, which act as a potent suppressor of the immune system by a myriad of …
(IC) proteins, which act as a potent suppressor of the immune system by a myriad of …
Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier
Recently, immune checkpoint inhibitors (ICIs) therapy has become a promising therapeutic
strategy with encouraging therapeutic outcomes due to their durable anti-tumor effects …
strategy with encouraging therapeutic outcomes due to their durable anti-tumor effects …
Trial watch: STING agonists in cancer therapy
Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an
endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from …
endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from …
Toxicity in combination immune checkpoint inhibitor and radiation therapy: A systematic review and meta-analysis
Background and purpose Immune checkpoint inhibitor with radiation therapy (ICI+ RT) is
under investigation for improved patient outcome, so we performed a systematic …
under investigation for improved patient outcome, so we performed a systematic …
Phase II trial of stereotactic ablative radiation for oligoprogressive metastatic kidney cancer
Background Patients with metastatic renal cell carcinoma (mRCC) treated with systemic
therapy sometimes progress at limited sites. The best treatment approach for patients with …
therapy sometimes progress at limited sites. The best treatment approach for patients with …
Stereotactic Ablative Radiation for Systemic Therapy–naïve Oligometastatic Kidney Cancer
Background Evidence-based guidelines for the management of systemic therapy–naïve
oligometastatic renal cell carcinoma (RCC) are lacking. Objective To evaluate the potential …
oligometastatic renal cell carcinoma (RCC) are lacking. Objective To evaluate the potential …
Stereotactic ablative radiotherapy combined with immune checkpoint inhibitors reboots the immune response assisted by immunotherapy in metastatic lung cancer: a …
R Chicas-Sett, I Morales-Orue… - International journal of …, 2019 - mdpi.com
Background: Immune checkpoint inhibitors (ICI) have represented a revolution in the
treatment of non-small-cell lung cancer (NSCLC). To improve these results, combined …
treatment of non-small-cell lung cancer (NSCLC). To improve these results, combined …
The emerging role of radiation therapy in renal cell carcinoma
M Christensen, R Hannan - Cancers, 2022 - mdpi.com
Simple Summary Stereotactic ablative radiation therapy (SAbR) is a safe and effective local
therapy for renal cell cancer (RCC) with emerging and evolving indications. In this review we …
therapy for renal cell cancer (RCC) with emerging and evolving indications. In this review we …
[HTML][HTML] Biomarkers for precision immunotherapy in the metastatic setting: hope or reality?
Precision immunotherapy is a crucial approach to improve the efficacy of anti-cancer
treatments, particularly in the metastatic setting. In this respect, accurate patient selection …
treatments, particularly in the metastatic setting. In this respect, accurate patient selection …
[HTML][HTML] Stereotactic ablative radiation therapy for oligoprogressive renal cell carcinoma
JE Schoenhals, O Mohamad, A Christie… - Advances in Radiation …, 2021 - Elsevier
Purpose Oligoprogression, defined as limited sites of progression on systemic therapy, in
patients with metastatic renal cell carcinoma (mRCC) is not uncommon, possibly because of …
patients with metastatic renal cell carcinoma (mRCC) is not uncommon, possibly because of …