The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
has led to a global pandemic. The 2019 coronavirus disease (COVID-19) presents with a …

Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a
systematic review Page 1 HEALTH TECHNOLOGY ASSESSMENT VOLUME 20 ISSUE 25 …

Background Therapy of severely affected coronavirus patient, requiring intubation and
sedation is still challenging. Recently, difficulties in sedating these patients have been …

This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

Background This systematic review and meta-analysis investigates the efficacy and safety of
clonidine as a sedative in critically ill patients requiring invasive mechanical ventilation …

Objectives: This systematic review and meta-analysis addresses the efficacy and safety of
nonopioid adjunctive analgesics for patients in the ICU. Data Sources: We searched …

Provision of adequate sedation is a fundamental part of caring for critically ill patients.
Propofol, dexmedetomidine, and benzodiazepines are the most commonly administered …

Purpose Little is known about the relationship between anxiety and pain in intensive care
unit (ICU) patients despite its importance. The aims of the present study are to examine the …

Purpose To review the efficacy and safety of transitioning from dexmedetomidine to
clonidine to facilitate weaning of patients from sedation with dexmedetomidine. There is a …

Objectives: Limited literature exists examining the use of enteral clonidine to transition
patients from dexmedetomidine for management of agitation. The aim of this study was to …