Simple Summary Breast and prostate cancers are serious public health issues that create
considerable burden to both people and healthcare systems worldwide. Cancer is a …

Deregulation of MYC is among the most frequent oncogenic drivers of cancer. Developing
targeted therapies against MYC is, therefore, one of the most critical unmet needs of cancer …

Tumors are intrinsically heterogeneous and it is well established that this directs their
evolution, hinders their classification and frustrates therapy,–. Consequently, spatially …

Making decisions on how best to treat cancer patients requires the integration of different
data sets, including genomic profiles, tumour histopathology, radiological images, proteomic …

Effective inhibition of the protein derived from cellular myelocytomatosis oncogene (c-Myc) is
one of the most sought-after goals in cancer therapy. While several c-Myc inhibitors have …

While skin is a site of active immune surveillance, primary melanomas often escape
detection. Here, we have developed an in silico model to determine the local cross-talk …

Tumors consist of different genotypically distinct subpopulations—or subclones—of cells.
These subclones can influence neighboring clones in a process called “clonal interaction.” …

Motivation Boolean networks are simple but efficient mathematical formalism for modelling
complex biological systems. However, having only two levels of activation is sometimes not …

The COVID-19 pandemic has pushed healthcare systems globally to a breaking point. The
urgent need for effective and affordable COVID-19 treatments calls for repurposing …

Tumor cells play a central role in multiple processes associated with cancer progression.
They continuously interact with surrounding cells and the extracellular matrix, displaying …