Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …

Myriad genetic and epigenetic alterations are required to drive normal cells toward
malignant transformation. These somatic events commandeer many signaling pathways that …

Neuronal death underlies the symptoms of many human neurological disorders, including
Alzheimer's, Parkinson's and Huntington's diseases, stroke, and amyotrophic lateral …

Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological
and behavioral functions of almost all species. This pattern is due to a fundamental …

Finding new strategies for the treatment of heart failures using stem cells has attracted a lot
of attention. Meanwhile, nanotechnology-based approaches to regenerative medicine …

In the very early stages of embryonic development, cells have the capability of dividing
indefinately and then differentiating into any type of cell in the body. Recent studies have …

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in
primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear …

Aging is associated with a rise in intracellular reactive oxygen species (ROS) and a loss of
telomerase reverse transcriptase activity. Incubation with H2O2 induced the nuclear export …

Normal human endothelial cells, like other somatic cells in culture, divide a limited number
of times before entering a nondividing state called replicative senescence. Expression of the …

Telomeres of human chromosomes contain a G-rich 3′-overhang that adopts an
intramolecular G-quadruplex structure in vitro which blocks the catalytic reaction of …