Nonlinear mixed effects models for data in the form of continuous, repeated measurements
on each of a number of individuals, also known as hierarchical nonlinear models, are a …

Highly active antiretroviral therapy (HAART) refers to a broad category of treatment regimens
usually comprised of three or more antiretroviral drugs that, in previously untreated HIV-1 …

Background and Methods Although potent antiretroviral therapy can control infection with
human immunodeficiency virus type 1 (HIV-1), a long-lived reservoir of infectious virus …

We have shown that nanoparticles (NPs) conjugated to trans-activating transcriptor (TAT)
peptide bypass the efflux action of P-glycoprotein and increase the transport of the …

Viral dynamics were intensively investigated in eight patients with acute HIV infection to
define the earliest rates of change in plasma HIV RNA before and after the start of …

Differential equation (DE) models are widely used in many scientific fields, including
engineering, physics, and biomedical sciences. The so-called “forward problem,” the …

We present an overview of some concepts and methodologies we believe useful in
modeling HIV pathogenesis. After a brief discussion of motivation for and previous efforts in …

While CD8+ T cells are clearly important in controlling virus replication during HIV and SIV
infections, the mechanisms underlying this antiviral effect remain poorly understood. In this …

Mathematical models of HIV-1 infection can help interpret drug treatment experiments and
improve our understanding of the interplay between HIV-1 and the immune system. We …

Background: Potent antiretroviral therapy (ART) with a protease inhibitor-based regimen is
commonly used to treat HIV-1-infected patients. Transient treatment interruptions because of …