The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

The liver is a central regulator of metabolism, and liver failure thus constitutes a major health
burden. Understanding how this complex organ develops during embryogenesis will yield …

Cirrhosis is a chronic condition that can lead to liver failure. Currently, the viable option for
decreasing mortality is liver transplantation. However, transplant surgery is highly invasive …

There exists a worldwide shortage of donor livers available for orthotropic liver
transplantation and hepatocyte transplantation therapies. In addition to their therapeutic …

Human pluripotent stem cell (hPSC) differentiation typically yields heterogeneous
populations. Knowledge of signals controlling embryonic lineage bifurcations could …

Members of the IL-6 cytokine family are involved in a variety of biological responses,
including the immune response, inflammation, hematopoiesis, and oncogenesis by …

Embryonic development of the liver has been studied intensely, yielding insights that impact
diverse areas of developmental and cell biology. Understanding the fundamental …

Recent development of improved tools and methods to analyse tissues at the three-
dimensional level has expanded our capacity to investigate morphogenesis of foetal liver …

The differentiation capacity of human embryonic stem cells (hESCs) holds great promise for
therapeutic applications. We report a novel three‐stage method to efficiently direct the …

During the past few years studies from several laboratories have utilized gene disruption
approaches to define the function of members of the Stat family of transcription factors. The …