Selectivity of phospholipid hydrolysis by phospholipase A2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization
AM Astudillo, MA Balboa, J Balsinde - … (BBA)-Molecular and Cell Biology of …, 2019 - Elsevier
Phospholipase A 2 s are enzymes that hydrolyze the fatty acid at the sn-2 position of the
glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of …
glycerol backbone of membrane glycerophospholipids. Given the asymmetric distribution of …
A new era of secreted phospholipase A2
M Murakami, H Sato, Y Miki, K Yamamoto… - Journal of lipid …, 2015 - ASBMB
Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …
Modulation of immunity by the secreted phospholipase A2 family
M Murakami, H Sato, Y Taketomi - Immunological reviews, 2023 - Wiley Online Library
Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …
Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition
M Murakami, Y Taketomi, Y Miki, H Sato, K Yamamoto… - Biochimie, 2014 - Elsevier
Within the phospholipase A 2 (PLA 2) superfamily, secreted PLA 2 (sPLA 2) enzymes
comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His …
comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His …
The roles of the secreted phospholipase A2 gene family in immunology
M Murakami, K Yamamoto, Y Miki, R Murase… - Advances in …, 2016 - Elsevier
Within the phospholipase A 2 (PLA 2) family that hydrolyzes phospholipids to yield fatty
acids and lysophospholipids, secreted PLA 2 (sPLA 2) enzymes comprise the largest group …
acids and lysophospholipids, secreted PLA 2 (sPLA 2) enzymes comprise the largest group …
Resolution pharmacology and the treatment of infectious diseases
VV Costa, F Resende, EM Melo… - British Journal of …, 2024 - Wiley Online Library
Inflammation is elicited by the host in response to microbes, and is believed to be essential
for protection against infection. However, we have previously hypothesized that excessive or …
for protection against infection. However, we have previously hypothesized that excessive or …
Group X secreted phospholipase A2 releases ω3 polyunsaturated fatty acids, suppresses colitis, and promotes sperm fertility
R Murase, H Sato, K Yamamoto, A Ushida… - Journal of Biological …, 2016 - ASBMB
Within the secreted phospholipase A 2 (sPLA 2) family, group X sPLA 2 (sPLA 2-X) has the
highest capacity to hydrolyze cellular membranes and has long been thought to promote …
highest capacity to hydrolyze cellular membranes and has long been thought to promote …
Lipoquality control by phospholipase A2 enzymes
M Murakami - Proceedings of the Japan Academy, Series B, 2017 - jstage.jst.go.jp
Abstract The phospholipase A 2 (PLA 2) family comprises a group of lipolytic enzymes that
typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and …
typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and …
Secretory Phospholipase A2 Enzymes in Acute Lung Injury
The secretory phospholipase A2 (sPLA2) group of secreted enzymes hydrolyze
phospholipids and lead to the production of multiple biologically active lipid mediators …
phospholipids and lead to the production of multiple biologically active lipid mediators …
Structure activity relationship and molecular docking of some quinazolines bearing sulfamerazine moiety as new 3CLpro, cPLA2, sPLA2 inhibitors
The current work was conducted to synthesize several novel anti-inflammatory quinazolines
having sulfamerazine moieties as new 3CLpro, cPLA2, and sPLA2 inhibitors. The thioureido …
having sulfamerazine moieties as new 3CLpro, cPLA2, and sPLA2 inhibitors. The thioureido …