[HTML][HTML] Alcoholic liver disease: pathogenesis and current management

NA Osna, TM Donohue Jr… - Alcohol research: current …, 2017 - ncbi.nlm.nih.gov
Excessive alcohol consumption is a global healthcare problem. The liver sustains the
greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol …

Pathogenesis of alcohol-associated liver disease

NA Osna, K Rasineni, M Ganesan… - Journal of Clinical and …, 2022 - Elsevier
Excessive alcohol consumption is a global healthcare problem with enormous social,
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …

Acute ethanol-induced liver injury is prevented by betaine administration

MK Arumugam, S Chava, SK Perumal, MC Paal… - Frontiers in …, 2022 - frontiersin.org
Binge drinking is the most common form of excessive alcohol use. Repeated episodes of
binge drinking cause multiple organ injuries, including liver damage. We previously …

Alcohol and hepatitis C virus–interactions in immune dysfunctions and liver damage

G Szabo, JR Wands, A Eken, NA Osna… - Alcoholism: Clinical …, 2010 - Wiley Online Library
Hepatitis C virus infection affects 170 million people worldwide, and the majority of
individuals exposed to HCV develop chronic hepatitis leading to progressive liver damage …

Role of ampk-srebp signaling in regulating fatty acid binding-4 (fabp4) expression following ethanol metabolism

N Attal, E Marrero, KJ Thompson, IH McKillop - Biology, 2022 - mdpi.com
Simple Summary Liver damage is a common occurrence following sustained, heavy alcohol
consumption. One of the earliest pathologies associated with alcohol-dependent liver …

In-vitro and in-vivo evaluation of the molecular mechanisms involved in the toxicity associated to CdSe/ZnS quantum dots exposure

E Garcia-Calvo, P Cabezas-Sanchez, JL Luque-Garcia - Chemosphere, 2021 - Elsevier
The use of different types of quantum dots is growing in recent times in both the technology
and biomedical industries. Such is the extension of the use of these quantum dots that they …

[HTML][HTML] Ethanol-induced oxidant stress modulates hepatic autophagy and proteasome activity

TM Donohue Jr, PG Thomes - Redox biology, 2014 - Elsevier
In this review, we describe research findings on the effects of alcohol exposure on two major
catabolic systems in liver cells: the ubiquitin–proteasome system (UPS) and autophagy …

Cytochrome P450 2E1‐dependent hepatic ethanol metabolism induces fatty acid‐binding protein 4 and steatosis

N Attal, E Marrero, KJ Thompson… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Background Hepatic steatosis is an early pathology of alcohol‐associated liver disease
(ALD). Fatty acid‐binding protein‐4 (FABP4, a FABP not normally produced in the liver) is …

Methamphetamine oxidatively damages parkin and decreases the activity of 26S proteasome in vivo

A Moszczynska, BK Yamamoto - Journal of neurochemistry, 2011 - Wiley Online Library
J. Neurochem.(2011) 116, 1005–1017. Abstract Methamphetamine (METH) is toxic to
dopaminergic (DAergic) terminals in animals and humans. An early event in METH …

Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity

B Nath, G Szabo - Seminars in liver disease, 2009 - thieme-connect.com
Alcoholic liver injury involves a complex array of derangements in cellular signaling of
hepatic parenchymal and nonparenchymal cells as well as cells of the immune system. In …