Hepatitis D virus in 2021: virology, immunology and new treatment approaches for a difficult-to-treat disease

S Urban, C Neumann-Haefelin, P Lampertico - Gut, 2021 - gut.bmj.com
Approximately 5% of individuals infected with hepatitis B virus (HBV) are coinfected with
hepatitis D virus (HDV). Chronic HBV/HDV coinfection is associated with an unfavourable …

Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

NA Terrault, ASF Lok, BJ McMahon, KM Chang… - …, 2018 - Wiley Online Library
This AASLD 2018 Hepatitis B Guidance is intended to complement the AASLD 2016
Practice Guidelines for Treatment of Chronic Hepatitis B (1) and update the previous …

A phase 3, randomized trial of bulevirtide in chronic hepatitis D

H Wedemeyer, S Aleman, MR Brunetto… - … England Journal of …, 2023 - Mass Medical Soc
Background Coinfection with hepatitis D virus (HDV) accelerates the progression of liver
disease associated with chronic hepatitis B. Bulevirtide inhibits the entry of HDV into …

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

P Lampertico, K Agarwal, T Berg, M Buti… - Journal of …, 2017 - Elsevier
Hepatitis B virus (HBV) infection remains a global public health problem with changing
epidemiology due to several factors including vaccination policies and migration. This …

Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis

HY Chen, DT Shen, DZ Ji, PC Han, WM Zhang, JF Ma… - Gut, 2019 - gut.bmj.com
Objective Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with
hepatitis B virus (HBV). The HBV with HDV super-infection has been considered as one of …

The changing context of hepatitis D

M Rizzetto, S Hamid, F Negro - Journal of hepatology, 2021 - Elsevier
The global epidemiology of hepatitis D is changing with the widespread implementation of
vaccination against hepatitis B. In high-income countries that achieved optimal control of …

Bulevirtide with or without pegIFNα for patients with compensated chronic hepatitis delta: From clinical trials to real-world studies

P Lampertico, D Roulot, H Wedemeyer - Journal of hepatology, 2022 - Elsevier
Chronic hepatitis D (CHD) is the most severe form of viral hepatitis, characterised by the
greatest increase in risk of cirrhosis, hepatic decompensation and hepatocellular carcinoma …

EASL Clinical Practice Guidelines on hepatitis delta virus

MR Brunetto, G Ricco, F Negro, H Wedemeyer… - Journal of …, 2023 - Elsevier
Hepatitis D virus (HDV) is a defective virus that requires the hepatitis B virus to complete its
life cycle and cause liver damage in humans. HDV is responsible for rare acute and chronic …

[PDF][PDF] Guidance for design and endpoints of clinical trials in chronic hepatitis B—report from the 2019 EASL‐AASLD HBV Treatment Endpoints Conference

M Cornberg, ASF Lok, NA Terrault, F Zoulim… - …, 2020 - Wiley Online Library
Representatives from academia, industry, regulatory agencies, and patient groups
convened in March 2019 with the primary goal of developing agreement on chronic hepatitis …

Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib/IIa study

P Bogomolov, A Alexandrov, N Voronkova… - Journal of …, 2016 - Elsevier
Background & Aims The therapeutic option for patients with chronic hepatitis delta virus
infection (CHD) is limited to interferon alpha with rare curative outcome. Myrcludex B is a first …